Harnessing the Power of Nutrients
Phosphatidylcholine and TMAO

Phosphatidylcholine and TMAO

Q&A Files #313 Early Release Podcast

If I am at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement?

This is a question asked live during the December 14, 2022 AMA.

Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. There are thousands of things that should be given equal weight as potential contributors to heart disease, but TMAO gets the most attention because the Cleveland Clinic has an incredible PR machine to spread their research, which serves to bolster their financial interest in marketing the test. That said, it is not a universal necessity to supplement with phosphatidylcholine. If you are concerned about your TMAO, you can try substituting trimethylglycine (TMG), and ultimately judge the value of each supplement by whether it is helping you in a demonstrable way.

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This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | December 14, 2022 AMA

Inositol, TMAO, undercarboxylated osteocalcin, liver enzymes, heart disease, methylation and selenium, and my twitching protocol.

The questions include:

  • Inositol, What Is It Good For?

  • If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation?

  • Maragen Calcium

  • Could slow methylation cause high selenium levels?

  • My current thoughts on cholesterol and heart disease

  • If I already have oxidative stress, what ducks should I have in a row before supplementing with iron?

  • Is it safe to take eight milligrams of zinc daily without copper?

  • What to do about developing sensitivities to an increasingly broad range of foods?

  • What else to do about hemochromatosis besides phlebotomy?

  • If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS?

  • What to do about chronically elevated amylase and lipase?

  • What to do about a non-drinker having very high GGT and occasionally high ALT?

  • What are the most common vitamin and mineral deficiencies?

  • What are the best supplements, vitamins, and minerals for OCD and depression?

  • What is the connection between low pyruvate and high ketones?

  • Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?

  • An algorithm to fix twitching

  • Do I trust food allergy tests?


I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

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