If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight?

If a person has a hereditary weakness for Branched Chain Amino Acid Catabolism would this impact the type of diet they might choose to loose weight? Should they limit protein if it will increase their need for nutrients like Biotin?What are all the possible cofactors we should consider supplementing to support Leucine catabolism?

This is a question asked live during the January 21, 2023 AMA.

Short Answer: Metabolizing branched-chain amino acids requires all B vitamins except folate, calcium, magnesium, potassium, and chloride. If you have a genetic impairment in this pathway, then reducing branched-chain amino acid intake and doubling down on cofactors is important during weight loss because the pathway will be stressed more in the catabolic state.

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This snippet is from the January 21, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | January 21, 2023 AMA

Plant compounds and heart disease, balancing omega-3 and omega-6 fatty acids, food intolerances, nutrient cofactors for genetic defects in branched-chain amino acid metabolism.

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I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

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