Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of “biological vitamin D activity” from them.
This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples from this batch here:
Questions on Vitamin D, Fatty Liver, HbA1c vs CGM, Turmeric and Testosterone, Fasting, and B6 Markers
In that batch of free episodes you will also find the answers to these questions:
Reversing Fatty Liver: How Long Does It Take?
What if my A1C says I'm diabetic but my CGM says I'm fine?
Will reishi, turmeric, or curcumin tank my testosterone?
The 3 Phases of Fasting: And How to Get Kicked Out of Each One
Why do my urinary B6 markers say I'm deficient if I'm supplementing and my plasma levels are high-normal?
If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.
This snippet is from the April 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
Ask Me Anything | April 13, 2022
Fat-soluble vitamins, prenatal nutrition, mixing glycine with aspirin, supplementing with alpha-ketoglutarate, nausea in pregnancy, and more.
The questions include:
How to balance vitamins E and K
What prenatal vitamin do I recommend?
Why does my smoothie make my hands cold?
What type of choline to use?
Is there an interaction between glycine and aspirin?
What supplements can be used in the fasting state?
How to manage protein intake within a small eating window on an intermittent fasting regimen?
Looking at a study on calcium alpha-ketoglutarate supplementation.
Should I take vitamin D for COVID if I easily get hypercalcemia from it?
What to do about nausea in pregnancy?
Brief questions on restless legs, exercise during fasting, puffy eyes, and health effects of spicy foods.
Disclaimer
I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.
Please Show This Post Some Love
Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.
Join the Next Live Q&A
Have a question for me? Ask it at the next Q&A! Learn more here.
Subscribe
Subscribe or upgrade your subscription here:
Join the Masterpass
Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:
Learn more about the Masterpass here.
Take a Look at the Store
At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.
For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.
For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.
For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.
What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR?