What cofactors are needed to synthesize and recycle BH4?

Question: What cofactors are needed to synthesize and recycle BH4?

This is a question asked live during the February 15, 2023 AMA.

Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).

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This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | February 15, 2023 AMA

Vitamin D sulfate, synthesis and recycling of BH4, high-dose iron absorption, management of PPI use, low creatine and muscle spasms, detoxing arsenic, iron saturation, and more.

The questions include:

• Is It Important to Get Vitamin D Sulfate Specifically From the Sun?

• How Much Iron Can We Absorb At Once?

• What nutrients are important for long-term PPI use?

• For how long does transferrin saturation respond to recent iron-rich food?

• Muscle spasms: creatine, creatinine, sodium, and potassium.

• Hematologists ignore iron saturation.

• How to detox arsenic?

• Could folic acid supplements impair BH4 recycling?

• How to increase butyrate?

• More on hematologists and transferrin saturation.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

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