Question: What cofactors are needed to synthesize and recycle BH4?
This is a question asked live during the February 15, 2023 AMA.
Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).
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This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
Ask Me Anything | February 15, 2023 AMA
Vitamin D sulfate, synthesis and recycling of BH4, high-dose iron absorption, management of PPI use, low creatine and muscle spasms, detoxing arsenic, iron saturation, and more.
The questions include:
Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?
What nutrients are important for long-term PPI use?
For how long does transferrin saturation respond to recent iron-rich food?
Muscle spasms: creatine, creatinine, sodium, and potassium.
Hematologists ignore iron saturation.
How to detox arsenic?
Could folic acid supplements impair BH4 recycling?
How to increase butyrate?
More on hematologists and transferrin saturation.
Disclaimer
I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.
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What cofactors are needed to synthesize and recycle BH4?