Questions on phosphatidylcholine, TMAO vitamin K2, undercarboxylated osteocalcin and my twitching protocol.

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Phosphatidylcholine and TMAO

Video

Podcast

Question: If I am at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement?

Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. There are thousands of things that should be given equal weight as potential contributors to heart disease, but TMAO gets the most attention because the Cleveland Clinic has an incredible PR machine to spread their research, which serves to bolster their financial interest in marketing the test. That said, it is not a universal necessity to supplement with phosphatidylcholine. If you are concerned about your TMAO, you can try substituting trimethylglycine (TMG), and ultimately judge the value of each supplement by whether it is helping you in a demonstrable way.

Vitamin K2 and Undercarboxylated Osteocalcin

Video

Podcast

Question: If undercarboxylated osteocalcin has health benefits, and vitamin K2 decreases it, what does that mean for K2 supplementation?

Short Answer: Vitamin K2 helps secure osteocalcin in bone matrix, where it is decarboxylated and released as an endocrine hormone in response to certain stimuli. When released, it acts to optimize insulin secretion, insulin sensitivity, fuel use during exercise, and male testosterone.

What to Do About Twitching

Video

Podcast

Question: What can be done about twitching?

Short Answer: Most twitching will be driven by glutamate/GABA balance or acetylcholine regulation, and the most likely nutritional issues are any of the electrolytes or any factor that influences energy metabolism. The best way to address it is to consider the conditions that influence it and then trial and error your way through each potential nutritional issue in order of which ones make the most sense for your individual case first."

The Full Recordings and Transcripts

These Q&A Files episodes are free snippets taken from three recent AMAs. To access the full recordings and transcripts, become a Masterpass member. You can learn more about it here. Get 10% off the membership fee using this link.

Here are the links that Masterpass members can use, as well as a preview of the content contained within them:

Ask Me Anything | December 14 AMA

Inositol, TMAO, undercarboxylated osteocalcin, liver enzymes, heart disease, methylation and selenium, and my twitching protocol.

The questions include:

• Inositol, What Is It Good For?

• If I am at risk of heart disease, and phosphatidylcholine raises my TMAO, should I stop the supplement?

• If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation?

• Maragen Calcium

• Could slow methylation cause high selenium levels?

• My current thoughts on cholesterol and heart disease

• If I already have oxidative stress, what ducks should I have in a row before supplementing with iron?

• Is it safe to take eight milligrams of zinc daily without copper?

• What to do about developing sensitivities to an increasingly broad range of foods?

• What else to do about hemochromatosis besides phlebotomy?

• If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS?

• What to do about chronically elevated amylase and lipase?

• What to do about a non-drinker having very high GGT and occasionally high ALT?

• What are the most common vitamin and mineral deficiencies?

• What are the best supplements, vitamins, and minerals for OCD and depression?

• What is the connection between low pyruvate and high ketones?

• Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?

• An algorithm to fix twitching

• Do I trust food allergy tests?

Click here to see when the next Q&A is or to register for it if you are a Masterpass member. You can learn more about it here. Get 10% off the membership fee using this link.

Thanks to everyone who participated, and I hope you find these useful!
Chris