I have Hemochromatosis. I was diagnosed with it nine years ago. This is interesting! That’s an understatement. I’ll be sharing this with a couple of large groups I’m in with people like me
Do we want to keep the manganase daily levels taken from food at 2mg per day even though we don't have the hemochromatosis mutations ? I am a regular drinker of Hibiscus tea which seems to be beneficial for someone that has a slow NO3 gene, but Hibiscus seems to be loaded with manganase with 1mg per cup of tea. I do not have any of the hemochromatis mutations.
If we have our whole genome sequenced with Sequencing.com, do you have any recommended calculators/apps we can use? I remember you referencing one from a Masterpass member in another article - is it possible to get access to that? Of course happy to pay. In the meantime, I've just been use Genome Explorer and inputting the genes. I have 4 SLC40A1 variants and heterozygous for HFE H63D/rs1799945. The 4:1 iron to manganese ratio is super helpful, but sounds like I should also be maybe having a bit lower iron'/manganese than the RDA due to these mutations? Do iron inhibitors (calcium, curcumin, quercitin) also inhibit manganese absorption?
So are we really in effect just talking about a silica deficiency in the diet?
And silica always seems to be best absorbed from natural, high-content silica-rich mineral waters. Something our modern world has lost as we no longer drink from fresh mountain streams and natural springs.
Those seeking to minimise manganese should also minimise liver consumption considering that the liver is where managanese is stored. Do you agree, Chris?
I have H63D with high iron saturation, and normal ferritin and iron. Borderline low to normal rbc. Doctors essentially don’t see anything. Should I be concerned? Btw, on low carb diet with plenty of meat.
Chris, iron overload is such an interest to me as mine comes from iron injections when I was 50 (30 years ago). I have the brown spots all over my hands. I’m too old to donate blood anyway so is there a solution? Presumably I don’t have corresponding excess manganese. Pretty healthy on the whole.
Thank you for this in depth article!! My 77 year old mother was just diagnosed with hemochromatosis and seems to have some artery blockages that she will have angioplasty for next week. Her cholesterol is high and she is having occasional chest pain along with aches and fatigue. She is convinced her heart issue is caused by the high iron, but the cardiologist won't discuss of course - not his lane so to speak. Her primary won't do anything until the cardiologist does his work. So she is told to relax, wait for the procedure and has nitro to take if she needs it. So maddening that so little connecting of dots seem to be done anymore!
My brother and I both have hemochromatosis. Our mom is 84 and just had her iron checked it is high. She has just started the tremors in her legs and can’t walk. Is there any hope to remove the toxins and have the tremors dissipate?
I'm heterozygous for the less severe hemochromatosis gene and my iron saturation was 50% when I tested last spring. I just checked and my multivitamin from Pure Encapsulations has 2 mg of manganese - is that likely too much to supplement for a multi as a a carrier? I eat nuts and coconut pretty regularly on my gluten free diet, which I'll be reducing my consumption of both after your latest articles!
I imagine it's better to have the iron and Mn balanced within a food, but do you think that keeping it balanced on a daily basis is good enough? Or maybe mixing high iron foods with high Mn foods within a meal ( ham on rye for example) ? Thanks for this article , I really appreciate the quantitative analysis, especially ratio metrics. I really believe all the rdas should be expressed as ratios... because it all comes down to stoichiometry eventually doesn't it
From what I understand, iron has little to no elimination pathways which leads to buildup in the body. Is the same true for manganese? Is there any knowledge on the elimination pathways of manganese?
My iron saturation as calculated by Quest has been a bit high the last year - 50% and now 52%, and functionhealth flagged this as a concern. My Dr. said not to worry - it's just a calculation - and my ferritin and iron levels look fine. I have genetic markers - I'm a carrier for hemochromatosis, but Dr. says that shouldn't matter since I'm just a carrier. I'm in perimenopause. In between the 50% calc and the 52% calc, I had a couple months of regular menstrual cycles, and saturation went down to 21, then back up. I think I need to donate blood. And no more hibiscus tea???
Very interesting, tank you ! I am heterozygous for the C282Y variant. I checked because I used to have all symptoms of iron overload (I still have but milder). I donated my blood a few times but it did not really fix my health. Now, after reading this, it might be because of the manganese (my liver enzymes are not great, which I always found weird because I have a really healthy life).
The one time I felt super great was after a 10 day fast + phlebotomy, but it lasted only 2-3 weeks. It might be because that time the iron loss was not compensated by the manganese intake (because of the fast).
The one think it does not explain, however, is why i tend to feel worse the day after a large meat intake.
Thanks again, only you go into that kind of detail that can change someone life.
I have Hemochromatosis. I was diagnosed with it nine years ago. This is interesting! That’s an understatement. I’ll be sharing this with a couple of large groups I’m in with people like me
I am glad to read this article. More people should know.
Do we want to keep the manganase daily levels taken from food at 2mg per day even though we don't have the hemochromatosis mutations ? I am a regular drinker of Hibiscus tea which seems to be beneficial for someone that has a slow NO3 gene, but Hibiscus seems to be loaded with manganase with 1mg per cup of tea. I do not have any of the hemochromatis mutations.
If we have our whole genome sequenced with Sequencing.com, do you have any recommended calculators/apps we can use? I remember you referencing one from a Masterpass member in another article - is it possible to get access to that? Of course happy to pay. In the meantime, I've just been use Genome Explorer and inputting the genes. I have 4 SLC40A1 variants and heterozygous for HFE H63D/rs1799945. The 4:1 iron to manganese ratio is super helpful, but sounds like I should also be maybe having a bit lower iron'/manganese than the RDA due to these mutations? Do iron inhibitors (calcium, curcumin, quercitin) also inhibit manganese absorption?
Wondering whether this is all just creating complexity by looking at secondary issues.
Silica has regulatory effects and protects against toxicity of metals such as iron & manganese.
Silica also enhances the positive effects of copper in the body, which is the key cofactor and regulator of iron in the body.
https://www.sciencedirect.com/science/article/abs/pii/095528639090086Z
So are we really in effect just talking about a silica deficiency in the diet?
And silica always seems to be best absorbed from natural, high-content silica-rich mineral waters. Something our modern world has lost as we no longer drink from fresh mountain streams and natural springs.
Those seeking to minimise manganese should also minimise liver consumption considering that the liver is where managanese is stored. Do you agree, Chris?
I have H63D with high iron saturation, and normal ferritin and iron. Borderline low to normal rbc. Doctors essentially don’t see anything. Should I be concerned? Btw, on low carb diet with plenty of meat.
Chris, iron overload is such an interest to me as mine comes from iron injections when I was 50 (30 years ago). I have the brown spots all over my hands. I’m too old to donate blood anyway so is there a solution? Presumably I don’t have corresponding excess manganese. Pretty healthy on the whole.
Thank you for this in depth article!! My 77 year old mother was just diagnosed with hemochromatosis and seems to have some artery blockages that she will have angioplasty for next week. Her cholesterol is high and she is having occasional chest pain along with aches and fatigue. She is convinced her heart issue is caused by the high iron, but the cardiologist won't discuss of course - not his lane so to speak. Her primary won't do anything until the cardiologist does his work. So she is told to relax, wait for the procedure and has nitro to take if she needs it. So maddening that so little connecting of dots seem to be done anymore!
My brother and I both have hemochromatosis. Our mom is 84 and just had her iron checked it is high. She has just started the tremors in her legs and can’t walk. Is there any hope to remove the toxins and have the tremors dissipate?
I'm heterozygous for the less severe hemochromatosis gene and my iron saturation was 50% when I tested last spring. I just checked and my multivitamin from Pure Encapsulations has 2 mg of manganese - is that likely too much to supplement for a multi as a a carrier? I eat nuts and coconut pretty regularly on my gluten free diet, which I'll be reducing my consumption of both after your latest articles!
I imagine it's better to have the iron and Mn balanced within a food, but do you think that keeping it balanced on a daily basis is good enough? Or maybe mixing high iron foods with high Mn foods within a meal ( ham on rye for example) ? Thanks for this article , I really appreciate the quantitative analysis, especially ratio metrics. I really believe all the rdas should be expressed as ratios... because it all comes down to stoichiometry eventually doesn't it
From what I understand, iron has little to no elimination pathways which leads to buildup in the body. Is the same true for manganese? Is there any knowledge on the elimination pathways of manganese?
My iron saturation as calculated by Quest has been a bit high the last year - 50% and now 52%, and functionhealth flagged this as a concern. My Dr. said not to worry - it's just a calculation - and my ferritin and iron levels look fine. I have genetic markers - I'm a carrier for hemochromatosis, but Dr. says that shouldn't matter since I'm just a carrier. I'm in perimenopause. In between the 50% calc and the 52% calc, I had a couple months of regular menstrual cycles, and saturation went down to 21, then back up. I think I need to donate blood. And no more hibiscus tea???
What's "iron overload"? High in our blood or high stored in our tissues with high ferritin?
Very interesting, tank you ! I am heterozygous for the C282Y variant. I checked because I used to have all symptoms of iron overload (I still have but milder). I donated my blood a few times but it did not really fix my health. Now, after reading this, it might be because of the manganese (my liver enzymes are not great, which I always found weird because I have a really healthy life).
The one time I felt super great was after a 10 day fast + phlebotomy, but it lasted only 2-3 weeks. It might be because that time the iron loss was not compensated by the manganese intake (because of the fast).
The one think it does not explain, however, is why i tend to feel worse the day after a large meat intake.
Thanks again, only you go into that kind of detail that can change someone life.