Very interesting, tank you ! I am heterozygous for the C282Y variant. I checked because I used to have all symptoms of iron overload (I still have but milder). I donated my blood a few times but it did not really fix my health. Now, after reading this, it might be because of the manganese (my liver enzymes are not great, which I always f…
Very interesting, tank you ! I am heterozygous for the C282Y variant. I checked because I used to have all symptoms of iron overload (I still have but milder). I donated my blood a few times but it did not really fix my health. Now, after reading this, it might be because of the manganese (my liver enzymes are not great, which I always found weird because I have a really healthy life).
The one time I felt super great was after a 10 day fast + phlebotomy, but it lasted only 2-3 weeks. It might be because that time the iron loss was not compensated by the manganese intake (because of the fast).
The one think it does not explain, however, is why i tend to feel worse the day after a large meat intake.
Thanks again, only you go into that kind of detail that can change someone life.
Is there any real evidence of manganese toxicity from plants?
I guess the biggest chances of that to happen would be for the person coming from high meat diets, overloaded with iron - with volumes of iron that takes years to clear - now adding extra high manganese to that, hmmm... maybe indeed.
So, the bottom line would be never ever start it with high iron foods, I'd say. Keep it normal levels while detoxing from iron and then, only after that, go more legumes, nuts, whole seeds.
Yes there is evidence, but it's conflicting and controversial.
I think you have the iron connection backwards. Being overloaded with iron causes lower absorption of manganese from food and iron displaces manganese in cells.
It is the genetic disruption of hepcidin function that matters, not having eaten meat.
Lol I did read your article and understood most everything but still messed up some connections at the time of writing this, indeed..
Really complex to grasp at one glance lol
Even with the hepcidin, the inflammatory states in the body play quite a big role.
Interesting how really big amounts of meats (in otherwise imbalanced diets) still promote more inflammatory states, and so more hepcidin is produced - iron availability decreased, iron locked into macrophages etc.
Very interesting, tank you ! I am heterozygous for the C282Y variant. I checked because I used to have all symptoms of iron overload (I still have but milder). I donated my blood a few times but it did not really fix my health. Now, after reading this, it might be because of the manganese (my liver enzymes are not great, which I always found weird because I have a really healthy life).
The one time I felt super great was after a 10 day fast + phlebotomy, but it lasted only 2-3 weeks. It might be because that time the iron loss was not compensated by the manganese intake (because of the fast).
The one think it does not explain, however, is why i tend to feel worse the day after a large meat intake.
Thanks again, only you go into that kind of detail that can change someone life.
Nothing creates manganese toxicity like being “healthy” unfortunately.
Manganese toxicity compromises sulfur amino acid handling. I’ll explain in near future.
Interesting.
Is there any real evidence of manganese toxicity from plants?
I guess the biggest chances of that to happen would be for the person coming from high meat diets, overloaded with iron - with volumes of iron that takes years to clear - now adding extra high manganese to that, hmmm... maybe indeed.
So, the bottom line would be never ever start it with high iron foods, I'd say. Keep it normal levels while detoxing from iron and then, only after that, go more legumes, nuts, whole seeds.
Yes there is evidence, but it's conflicting and controversial.
I think you have the iron connection backwards. Being overloaded with iron causes lower absorption of manganese from food and iron displaces manganese in cells.
It is the genetic disruption of hepcidin function that matters, not having eaten meat.
Lol I did read your article and understood most everything but still messed up some connections at the time of writing this, indeed..
Really complex to grasp at one glance lol
Even with the hepcidin, the inflammatory states in the body play quite a big role.
Interesting how really big amounts of meats (in otherwise imbalanced diets) still promote more inflammatory states, and so more hepcidin is produced - iron availability decreased, iron locked into macrophages etc.
Thanks, look forward to reading your explanation. Any idea, in the meantime, to mitigate this ? Just eating less meat ?
Probably need to lower your manganese, which means eating less plants.
See here: https://chrismasterjohnphd.substack.com/p/coq10-deficiency-is-sulfur-toxicity
Thank you !