In my case my 23andme report show that my DHFR is normal, but I have t677t MTHFR, my homocysteine while taking Folic Acid and riboflavin was 9.5 a year ago, does this means that I can process FA and the B2 is compensating for my t677t?
Thanks for your reply, I uploaded the raw data to Promethease and my DHFR is normal, sorry for the confusion. But I’m still debating whether I can safely take folic acid in supplements while supplementing with B2 since I can’t tolerate Methylfolate or Folinic Acid.
I have high serine and low glycine on tests and this supplement has been really calming to me with a similar effect to supplementing glycine. I made a mistake a year ago by overdosing on TMG (10 capsules a day for a week) and my THF is really low, recovery has been slow.
I don’t know THF of any specific powder but sounds like high in general from this https://pmc.ncbi.nlm.nih.gov/articles/PMC4711403/ which is why I was wondering if it’s a possible alternative to romaine?
Table 1 indicates it is 25% THF, which would be a good source assuming it is preserved in the powdering process and you get the equivalent of 100 grams of fresh leaves.
Grok seems to suggest that L-5-methyltetrahydrofolate might be superior: "L-5-methyltetrahydrofolate, though, is a step further—it’s THF that’s already been methylated, making it the ready-to-roll version your body uses directly in the methylation cycle (e.g., turning homocysteine into methionine)."
The fact it's further along in the cycle is exactly why it can be harmful for some people. There are important pathways on the way to creating methylfolate that are skipped, which are involved in creating and processing several other nutrients.
Thank you for giving me an unexpected anxiety attack. This brings back my college days. Not so much the chemistry, but my fraternity days. Geez!
Thanks a lot for this. I always had the feeling that I dont quite get folate and this made it much clearer!
In my case my 23andme report show that my DHFR is normal, but I have t677t MTHFR, my homocysteine while taking Folic Acid and riboflavin was 9.5 a year ago, does this means that I can process FA and the B2 is compensating for my t677t?
23andMe cannot show anything to be normal.
A snapshot in one condition cannot show what anything was doing.
3.2 mg total riboflavin (diet plus supplements) normalizes the effect of C677T.
Thanks for your reply, I uploaded the raw data to Promethease and my DHFR is normal, sorry for the confusion. But I’m still debating whether I can safely take folic acid in supplements while supplementing with B2 since I can’t tolerate Methylfolate or Folinic Acid.
If folic acid can raise THF but the limitation is the slow speed of DHFR, can the unmethylated folate (from Citrus Lemon Extract) help?
https://www.amazon.com/gp/product/B078P41WG9/ref=ewc_pr_img_1?smid=AQ9D9YX2TEHKA&psc=1
I have high serine and low glycine on tests and this supplement has been really calming to me with a similar effect to supplementing glycine. I made a mistake a year ago by overdosing on TMG (10 capsules a day for a week) and my THF is really low, recovery has been slow.
You'll have to find what the actual compound in this product is. I don't see it by glancing at the sales page.
Hi, have you any thoughts on Moringa powder as a source of THF?
Please post a link to the data on the THF content of this powder.
I don’t know THF of any specific powder but sounds like high in general from this https://pmc.ncbi.nlm.nih.gov/articles/PMC4711403/ which is why I was wondering if it’s a possible alternative to romaine?
Table 1 indicates it is 25% THF, which would be a good source assuming it is preserved in the powdering process and you get the equivalent of 100 grams of fresh leaves.
Hi Chris do you have a lecture on interleukins and mmp’s and how they would affect collagen production?
I take a supplement from Life Extension that has L-5-methyltetrahydrofolate calcium salt in it. (It also has B12.)
https://www.amazon.com/Life-Extension-Vitamin-Vegetarian-Capsules/dp/B019YGJLNM
Could it be an absorbable version of THF?
This is methylfolate.
Grok seems to suggest that L-5-methyltetrahydrofolate might be superior: "L-5-methyltetrahydrofolate, though, is a step further—it’s THF that’s already been methylated, making it the ready-to-roll version your body uses directly in the methylation cycle (e.g., turning homocysteine into methionine)."
The fact it's further along in the cycle is exactly why it can be harmful for some people. There are important pathways on the way to creating methylfolate that are skipped, which are involved in creating and processing several other nutrients.