This was such a fascinating read. Is there any chance that you have an issue with acetaldehyde levels? I recently read a pub med study that stated “We found that chronic exposure of NCM460 human colonic epithelial cells as well as human differentiated colonoid monolayers, to alcohol metabolites (acetaldehyde, ethyl palmitate, ethyl oleate) significantly inhibited biotin uptake and SMVT expression”. I do not drink alcohol ever but this seems to be the explanation for my chronically low biotin and vitamin A (retinoic acid) levels. Maybe I have reduced function of acetaldehyde dehydrogenase? I was addressing this with niacin but correcting my vitamin A with the recent large dose seems to have greatly reduced my need for biotin and opened up the way for me to take B6 which just might allow me to put niacin on the shelf. Just my current theory. Thanks for giving us a front seat to all this great data. It’s so helpful in getting a clearer understanding of the relationships between nutrients.
So many questions! Are they now directly measuring K2? I moved to the desert for access to sun and have gotten increasingly unwell. Could it be folate-related even though my folate levels are always too high to measure in LabCorp-type tests. I also have discovered by trial and error that I need far more vitamin A than is usually recommended. I would like to take the vibrant test.
Such a great comparison. THANKS for doing this! Sorry for this question but I got a little confused: Are you saying that Vibrant might be a good option to ADD on to what's in your nutritional cheat sheet (which has the Genova ION /organic acids plus all the different B's and other single line-items?). Or did you mean Vibrant can REPLACE Genova ION... I am not seeing organic acids on Vibrant Micronutrient Panel...
This was such a fascinating read. Is there any chance that you have an issue with acetaldehyde levels? I recently read a pub med study that stated “We found that chronic exposure of NCM460 human colonic epithelial cells as well as human differentiated colonoid monolayers, to alcohol metabolites (acetaldehyde, ethyl palmitate, ethyl oleate) significantly inhibited biotin uptake and SMVT expression”. I do not drink alcohol ever but this seems to be the explanation for my chronically low biotin and vitamin A (retinoic acid) levels. Maybe I have reduced function of acetaldehyde dehydrogenase? I was addressing this with niacin but correcting my vitamin A with the recent large dose seems to have greatly reduced my need for biotin and opened up the way for me to take B6 which just might allow me to put niacin on the shelf. Just my current theory. Thanks for giving us a front seat to all this great data. It’s so helpful in getting a clearer understanding of the relationships between nutrients.
Interesting comparison. Thanks for sharing it.
Have you checked your genetic data for biotinadase (BTD) variants? https://www.geneticlifehacks.com/genetics-of-biotin-deficiency/
So many questions! Are they now directly measuring K2? I moved to the desert for access to sun and have gotten increasingly unwell. Could it be folate-related even though my folate levels are always too high to measure in LabCorp-type tests. I also have discovered by trial and error that I need far more vitamin A than is usually recommended. I would like to take the vibrant test.
Such a great comparison. THANKS for doing this! Sorry for this question but I got a little confused: Are you saying that Vibrant might be a good option to ADD on to what's in your nutritional cheat sheet (which has the Genova ION /organic acids plus all the different B's and other single line-items?). Or did you mean Vibrant can REPLACE Genova ION... I am not seeing organic acids on Vibrant Micronutrient Panel...
Could you comment on the costs of the Vibrant snd Spectracell test for out of pocket costs?
I am interested, but my insurance won’t pay.