In “Genes, LDL-Cholesterol Levels, and the Central Role of LDL Receptor Activity in Heart Disease,” as well as my most recent presentations at Wise Traditions and AHS, I described the overwhelming genetic evidence for the theory that LDL receptor activity centrally governs the risk of heart disease and the large amount of other evidence from human and animal experiments that offers further support for this theory.
Reminds me of Dr. Broda Barnes' findings on thyroid hormone and heart disease - https://youtu.be/YFEGcOo-QpQ?t=518