Scientific expertise blended with out-of-the-box thinking for new practical ideas you can use to help yourself on your journey to vibrant health, by Chris Masterjohn, PhD.
Wow! You are really serious about this optimization stuff, aren't you! I can't believe it. This appears at a good time for me as I have been trying to optimize my blood pressure (with lots of problems) and I am having trouble with changing variables and meds, etc. I will definitely take a more in depth look at this. Thank you for the effort you took to do this and sharing it with us.
It is such a profound realization to see life and energy as a flowing, quantum space through which we navigate — projecting and perceiving it in our own unique ways. I feel immense joy in the synchronicity that has brought me to your work at this very moment.
Your passion for uncovering and decoding the very foundations of life is truly inspiring. What you have created is not only knowledge but also a complement to what so many of us feel deep within — the desire to understand, to heal, and to sustain the flow of energy that gives us life.
I can only praise and thank you for this remarkable contribution you’ve made to all of us. Personally, I feel a great passion to learn the metabolic pathways as you describe them, and to explore the incredible healing power of nutrients that sustain our vitality.
Congratulations once again for your extraordinary work and dedication — it is a gift to us all.
Hiya - excellent! This is roughly also how I long worked - diligent and detailed, sometimes using graphs if my daily blog using a template wasn't enough, but not quite *that detailed ;-).
An extremely important difference for me to above charts etc. aside from dose adjustment etc. however is the delicate balance of "main" to "side" effects or rather: good to harmful effects.
One of my first encounters was amitriptyline: 1 slipshod "main" effect on sleep and finally 8 "side" effects incl. increased seizures. Whilst all other meds (except LDN, starting "VLDN") had so harmful effects or developed them that it wasn't worth waiting for beneficial effects.
A complicated one I had to go into "graphic detail" on was acupuncture by a Chinese doc. Westerners only hurt me, but this actually did help a bit, without seeming to hurt. Improved my energy from ~15 to ~20-25%. But charting it, I discovered in relation to the treatment times that that was only for a few days and not consistent (altho clearly from it), and adding the effect on my sleep, I realised the net effect again wasn't worth it. Via this I came to the supposition it was stimulating my cortisol, but that as often was exploiting my reserves and increasing histamine.
A third recent example is closer to supps: I changed my magnesium to threonate and my glutathione to liposomal. Nothing else. Astonishingly I pretty suddenly got long-term constipation (altho life-long ISB-D). Didn't take it seriously enough and ended up with an abscess, altho completely dropping the threonate helped a bit, whilst dropping the lip. glutathione didn't. Still at a loss to explain this except it doing something to my gut long-term. Full dose lactulose is now helping, also prebiotic plus good for my lipids.
All these harmful effects from almost everything can creep up pretty insidiously... And docs like to say we'll get used to them, or nocebo - nope, not me....
(Altogether now I've done pretty much all I apparently can, so I've gone more into acceptance-mode of the rest, and my optimisation-style has got even rougher - but I still track around 10 symptoms and their treatments. And the last example shows how threatening it is to get too lax ;-).)
In my framework, you pull back upon adverse effect. The ideal thing is to find the path to benefit without tradeoff, which mostly exists outside of pharma.
So very true. All (my) supps are much more pleiotropic than other treatments, but even the trialling time was/is generally much less harmful (and short), and the 30+ (single) substances I've ended on had/have little to no tradeoffs during trialling and now - and if little, I can compensate with others.
So I suppose I'm just emphasising the *multiple effects, positive and negative, that you mention, which above graphs etc. illustrate the sum of.
Mind-blowing! You have an incredible superpower! I wish more doctors thought like you. Thanks for sharing your beautiful mind with us. I admire you beyond words.
I will be writing another post about how doctors do not understand doctoring and especially do not understand evidence-based medicine until they understand what I have written here. What is incredibly mind-blowing is that the founders of evidence-based medicine would endorse what I have written here and would indeed say that understanding this is the key to doctoring, but that none of the current purveyors of evidence-based medicine understand this at all.
Wow! You are really serious about this optimization stuff, aren't you! I can't believe it. This appears at a good time for me as I have been trying to optimize my blood pressure (with lots of problems) and I am having trouble with changing variables and meds, etc. I will definitely take a more in depth look at this. Thank you for the effort you took to do this and sharing it with us.
It is such a profound realization to see life and energy as a flowing, quantum space through which we navigate — projecting and perceiving it in our own unique ways. I feel immense joy in the synchronicity that has brought me to your work at this very moment.
Your passion for uncovering and decoding the very foundations of life is truly inspiring. What you have created is not only knowledge but also a complement to what so many of us feel deep within — the desire to understand, to heal, and to sustain the flow of energy that gives us life.
I can only praise and thank you for this remarkable contribution you’ve made to all of us. Personally, I feel a great passion to learn the metabolic pathways as you describe them, and to explore the incredible healing power of nutrients that sustain our vitality.
Congratulations once again for your extraordinary work and dedication — it is a gift to us all.
Hiya - excellent! This is roughly also how I long worked - diligent and detailed, sometimes using graphs if my daily blog using a template wasn't enough, but not quite *that detailed ;-).
An extremely important difference for me to above charts etc. aside from dose adjustment etc. however is the delicate balance of "main" to "side" effects or rather: good to harmful effects.
One of my first encounters was amitriptyline: 1 slipshod "main" effect on sleep and finally 8 "side" effects incl. increased seizures. Whilst all other meds (except LDN, starting "VLDN") had so harmful effects or developed them that it wasn't worth waiting for beneficial effects.
A complicated one I had to go into "graphic detail" on was acupuncture by a Chinese doc. Westerners only hurt me, but this actually did help a bit, without seeming to hurt. Improved my energy from ~15 to ~20-25%. But charting it, I discovered in relation to the treatment times that that was only for a few days and not consistent (altho clearly from it), and adding the effect on my sleep, I realised the net effect again wasn't worth it. Via this I came to the supposition it was stimulating my cortisol, but that as often was exploiting my reserves and increasing histamine.
A third recent example is closer to supps: I changed my magnesium to threonate and my glutathione to liposomal. Nothing else. Astonishingly I pretty suddenly got long-term constipation (altho life-long ISB-D). Didn't take it seriously enough and ended up with an abscess, altho completely dropping the threonate helped a bit, whilst dropping the lip. glutathione didn't. Still at a loss to explain this except it doing something to my gut long-term. Full dose lactulose is now helping, also prebiotic plus good for my lipids.
All these harmful effects from almost everything can creep up pretty insidiously... And docs like to say we'll get used to them, or nocebo - nope, not me....
(Altogether now I've done pretty much all I apparently can, so I've gone more into acceptance-mode of the rest, and my optimisation-style has got even rougher - but I still track around 10 symptoms and their treatments. And the last example shows how threatening it is to get too lax ;-).)
In my framework, you pull back upon adverse effect. The ideal thing is to find the path to benefit without tradeoff, which mostly exists outside of pharma.
So very true. All (my) supps are much more pleiotropic than other treatments, but even the trialling time was/is generally much less harmful (and short), and the 30+ (single) substances I've ended on had/have little to no tradeoffs during trialling and now - and if little, I can compensate with others.
So I suppose I'm just emphasising the *multiple effects, positive and negative, that you mention, which above graphs etc. illustrate the sum of.
- So much perfect detail here in everything!
Mind-blowing! You have an incredible superpower! I wish more doctors thought like you. Thanks for sharing your beautiful mind with us. I admire you beyond words.
I will be writing another post about how doctors do not understand doctoring and especially do not understand evidence-based medicine until they understand what I have written here. What is incredibly mind-blowing is that the founders of evidence-based medicine would endorse what I have written here and would indeed say that understanding this is the key to doctoring, but that none of the current purveyors of evidence-based medicine understand this at all.
Charlie Kirk diet
What did he eat?
Oh, I dunno, just makes good click bait..
meat & potatoes? 😏 guessing opposite the leftist vegan, low T, mental illness diet of his assassin.