What an incredibly well-rounded article! The complexity of our biology is both fascinating and scary - especially when you notice things going out of balance. Thank you for the great work and, as always, looking forward to learning more.
Everything sounds so complex about nutrition,so many if this then maybe that or it could be this gene or that gene.very interesting if one wants to go down the rabbit hole but it makes me just say I give up,Russian Roulete comes to mind lol
These articles make me day, I do not exaggerate. Incredibly thorough and insightful. I see now how a backup in complex III could cause an adverse reaction to Coq10, but couldn’t the same be said for the transsulfuration pathway? If one has less than optimal levels of b6 or molybdenum, like you spoke about in your protein article, couldn’t that cause a reaction to Coq10 in someone who would normally benefit from it because that pathway is not working optimally? And that could cause another vicious loop because b6 is needed for copper absorption, which then backs up complex IV? It’s all so complicated but so fascinating.
Thanks Chris, I think we all appreciate your burst of short articles these past weeks. Please keep it up!
Quick Q on this one then some comments - you mention a connection about high Manganese impairing CoQ10 and the involvement of sulfite processes. What if you're low in both? Can it be deduced that high sulfites without enough moly be independently sufficient to cause both low levels?
I'm not enough of an expert to conclude anything with confidence but it is my bet that because of your previous work and the fact my HMG is near 0 I must be making plenty of CoQ10 but something is destroying it.
I ordered the PH strips + Moly which will be in soon and will trial your suggested experiments next week. The only thing that still perplexes me is the role of taurine. I don't eat/drink anything with taurine yet I'm at 100%ile which you say should cap the production of sulfites, but if sulfites are impairing both manga/coq10 with taurine at 100 could that suggest that taurine alone is not the answer? ATM I believe it all comes back to Moly but i will find out more next week and if useful will share my results.
Is the upper limit recommendation for manganese intake still 11 mg, as mentioned in the cheat sheet? I use a lot of oats, which are rich in manganese, and my daily intake is just 11 mg. HFEs are both CC and GG, so no effect, but TMPRSS6 heterogeneous increases total iron binding capacity.
And add on question, is taurine a good "protector" in a rich manganese intake?
I have high urinary sulfite and can't get it to go down despite the added molybdenum. I am homozygous for cbs 360 and homozygous for mthfr 677 and heterozygous for suox. I've been using the Mthfr protocol for two years and it's better, but I still have brain fog. Can I try taking taurine to reduce sulphites?
My ION+40 results showed my serum CoQ10 level at 2.35 mcg/mL, well above the reference range of 0.46-1.72. So I take that to mean I am unlikely to have a sulfite or manganese toxicity, right?
Not sure if this is the best place to post this, but how do you generally try to treat sulfur toxicity once you decide that you think it's likely?
Obviously low sulfur diet, but what are some good supplements to experiment with that might help or other things?
Molybdenum, High dose CoQ10 or Riboflavin, L-carnitine, High dose b1, alpha-lipoic acid? Any good ones come to mind?
Is there a deeper root cause of this such as a nutrient deficiency or gut issue that could be resolved, or is this usually due to genes and best resolved with a megadose of something depending on the individual? If so, what are some supplements that have helped others that might be worth experimenting with?
Interesting! I've been following Dr. Mark Pimentel at Cedars Sinai and his work mapping the small intestine biome to sort out SIBO and IBS. They recently developed an expanded breath test to detect hydrogen sulfide in addition to the standard hydrogen and methane gas. I had elevated Desulfovibrio piger on a stool test and am treating with oregano oil, bismuth and berberine.
What an incredibly well-rounded article! The complexity of our biology is both fascinating and scary - especially when you notice things going out of balance. Thank you for the great work and, as always, looking forward to learning more.
Terrific info. Does coq10 supplementation run a risk of depleting riboflavin?
Everything sounds so complex about nutrition,so many if this then maybe that or it could be this gene or that gene.very interesting if one wants to go down the rabbit hole but it makes me just say I give up,Russian Roulete comes to mind lol
These articles make me day, I do not exaggerate. Incredibly thorough and insightful. I see now how a backup in complex III could cause an adverse reaction to Coq10, but couldn’t the same be said for the transsulfuration pathway? If one has less than optimal levels of b6 or molybdenum, like you spoke about in your protein article, couldn’t that cause a reaction to Coq10 in someone who would normally benefit from it because that pathway is not working optimally? And that could cause another vicious loop because b6 is needed for copper absorption, which then backs up complex IV? It’s all so complicated but so fascinating.
Thanks Chris, I think we all appreciate your burst of short articles these past weeks. Please keep it up!
Quick Q on this one then some comments - you mention a connection about high Manganese impairing CoQ10 and the involvement of sulfite processes. What if you're low in both? Can it be deduced that high sulfites without enough moly be independently sufficient to cause both low levels?
I'm not enough of an expert to conclude anything with confidence but it is my bet that because of your previous work and the fact my HMG is near 0 I must be making plenty of CoQ10 but something is destroying it.
I ordered the PH strips + Moly which will be in soon and will trial your suggested experiments next week. The only thing that still perplexes me is the role of taurine. I don't eat/drink anything with taurine yet I'm at 100%ile which you say should cap the production of sulfites, but if sulfites are impairing both manga/coq10 with taurine at 100 could that suggest that taurine alone is not the answer? ATM I believe it all comes back to Moly but i will find out more next week and if useful will share my results.
Thank you so much Chris.
I clearly have anxiety the day after a large meat intake. This really sounds like me.
I'll definitely take CoQ10 (I was taking 50m, I suppose I'll take 250).
And I'll give it a try with taurine (I suppose 1000 mg)
Is the upper limit recommendation for manganese intake still 11 mg, as mentioned in the cheat sheet? I use a lot of oats, which are rich in manganese, and my daily intake is just 11 mg. HFEs are both CC and GG, so no effect, but TMPRSS6 heterogeneous increases total iron binding capacity.
And add on question, is taurine a good "protector" in a rich manganese intake?
I have high urinary sulfite and can't get it to go down despite the added molybdenum. I am homozygous for cbs 360 and homozygous for mthfr 677 and heterozygous for suox. I've been using the Mthfr protocol for two years and it's better, but I still have brain fog. Can I try taking taurine to reduce sulphites?
Fascinating. The only supplement I know with sulfur in it is Sulforaphane. Would a CoQ10 supplement negate the positive effects of sulforaphane?
My ION+40 results showed my serum CoQ10 level at 2.35 mcg/mL, well above the reference range of 0.46-1.72. So I take that to mean I am unlikely to have a sulfite or manganese toxicity, right?
Not sure if this is the best place to post this, but how do you generally try to treat sulfur toxicity once you decide that you think it's likely?
Obviously low sulfur diet, but what are some good supplements to experiment with that might help or other things?
Molybdenum, High dose CoQ10 or Riboflavin, L-carnitine, High dose b1, alpha-lipoic acid? Any good ones come to mind?
Is there a deeper root cause of this such as a nutrient deficiency or gut issue that could be resolved, or is this usually due to genes and best resolved with a megadose of something depending on the individual? If so, what are some supplements that have helped others that might be worth experimenting with?
Hmmm, I keep thinking about this. Have you investigated sulforaphane in another article?
Interesting! I've been following Dr. Mark Pimentel at Cedars Sinai and his work mapping the small intestine biome to sort out SIBO and IBS. They recently developed an expanded breath test to detect hydrogen sulfide in addition to the standard hydrogen and methane gas. I had elevated Desulfovibrio piger on a stool test and am treating with oregano oil, bismuth and berberine.
Please keep posting! It is getting more and more interesting every time :)
Not related to the article but I wonder whether the microbiome may affect the trans sulphuration pathway.
For example can an overgrowth of sulfate reducing bacteria up regulate genes involved in that pathway ?