304: Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline?
Masterjohn Q&A Files Episode 304
Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline?
Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in people who do not experience cognitive decline. Cognitive decline does appear to be driven by decreases in brain energy metabolism, but these are not best described as a specific impairment in glucose handling. MCT oil can be modestly beneficial and a ketogenic diet can probably be somewhat more beneficial in people who have cognitive decline from any type. There is no evidence to support using it as a preventative. For prevention, I believe we should focus on aerobic fitness, nutrients required for healthy energy metabolism and antioxidant defense, and maintaining metabolic health with a healthy body composition and a healthy physical activity routine that includes the proper spread of a portfolio of different types of exercise.
This episode was cut from the original Q&A session that you can find here.
DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.
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