Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat.
This episode was cut from the original Q&A session that you can find here.
DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.
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