Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite of an apple. It requires the preponderance of signaling.
This episode was cut from the original Q&A session that you can find here.
DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.
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