Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of “biological vitamin D activity” from them.
This episode was cut from the original Q&A session that you can find here.
DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.
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