Good stuff, I have experienced similar results after starting the MTHFR protocol. It’s been 2 years now and results are permanent. I will add that all of my inflammation and joint pain has gone away as well. I’m a little older than Beth C. So that was an issue for me as well.
I have Mediterranean G6PD, tested at 0.8 (ref range 8.8-16.6) i.e. 5-10% normal activity. (Squarely the bottleneck in my Pentose Phosphate Pathway) In addition to poorly recycling glutathione and making limited ATP, I'm also not making NADPH for MTHFR...?
AND... my MTHFR is impaired. (C677T +/+)
Supplementing with megadose B-2 for a long time (300-400mg 2x/day) seems to help. (Does riboflavin vs R5P matter?)
Been using a few different B Complex supplements that have 50-100mg Niacin. (Does niacinamide vs inositol hexaniacinate matter?) They have 400-500mcg B12. (Does methylcobalamin vs dibencozide matter?)
Trying to sort this all out while also figuring out copper, zinc, my iron overload, and my potential manganese overload.
SLC19A1 folate transport polymorphism should be added as research states that solving MTHFR in this case is not enough. Also, some research from 2023 states that this transporter impacts thiamine. I have both, main MTHFR homoz and SCL19A1 homoz. Finally, Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes. Vitamin D works as an expression agonist, so I’m supplementing 5.000 UI/d. Should RBC folate be checked? Should SAMe be used? Should higher folate dose than 800mcg be used? Thank you.
Hi Dr. Masterjohn! Quick question, would you recommend a RhoGAM shot for an RH-negative pregnant woman (second pregnancy—first pregnancy was an RH-positive baby) with a positive Coombs test? Or would you decline the RhoGAM? Looking for resources as I’d like to avoid it but I am not sure what to do! Have heard that people with RH-negative blood are likely to have MTHFR. Thank you for your time!
Lifesaver!
Good stuff, I have experienced similar results after starting the MTHFR protocol. It’s been 2 years now and results are permanent. I will add that all of my inflammation and joint pain has gone away as well. I’m a little older than Beth C. So that was an issue for me as well.
Thanks Chris,
Scott F.
Would A1298C homozygous with BHMT 02,04,08 combination cause methylation issues?
Trying to wrap my head around NADPH and MTHFR...
I have Mediterranean G6PD, tested at 0.8 (ref range 8.8-16.6) i.e. 5-10% normal activity. (Squarely the bottleneck in my Pentose Phosphate Pathway) In addition to poorly recycling glutathione and making limited ATP, I'm also not making NADPH for MTHFR...?
AND... my MTHFR is impaired. (C677T +/+)
Supplementing with megadose B-2 for a long time (300-400mg 2x/day) seems to help. (Does riboflavin vs R5P matter?)
Been using a few different B Complex supplements that have 50-100mg Niacin. (Does niacinamide vs inositol hexaniacinate matter?) They have 400-500mcg B12. (Does methylcobalamin vs dibencozide matter?)
Trying to sort this all out while also figuring out copper, zinc, my iron overload, and my potential manganese overload.
SLC19A1 folate transport polymorphism should be added as research states that solving MTHFR in this case is not enough. Also, some research from 2023 states that this transporter impacts thiamine. I have both, main MTHFR homoz and SCL19A1 homoz. Finally, Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes. Vitamin D works as an expression agonist, so I’m supplementing 5.000 UI/d. Should RBC folate be checked? Should SAMe be used? Should higher folate dose than 800mcg be used? Thank you.
Hi Dr. Masterjohn! Quick question, would you recommend a RhoGAM shot for an RH-negative pregnant woman (second pregnancy—first pregnancy was an RH-positive baby) with a positive Coombs test? Or would you decline the RhoGAM? Looking for resources as I’d like to avoid it but I am not sure what to do! Have heard that people with RH-negative blood are likely to have MTHFR. Thank you for your time!
Does methylation have anything to do with having higher blood pressure? It runs in my family.
this is a great summary of a very intricate topic.
On a different note
I bought the pre-book of your Vitamins and Minerals but haven't received it. Do you have an update on this?