Absolutely fascinating deep dive into mitochondrial’s many functions. Mitome looks to be a very personalized tool in understanding our own unique physiology. I’ve been an elite athlete for most of my 68 years and have used bio impedance testing on myself and with clients. Always found it hilarious that these tests repeatedly identified my “mitochondrial age” to be TWELVE when I was chronologically 65! I’m still an extremely lean, muscular lady requiring an enormous amount of calories. Mitome may provide some answers. 🤷🏼♀️ Thank you!
Hi Chris! Thank you for the deep dive into serotonine! I am very much interested in perioheral actions if serotonine, which seems to be very complex. In the study https://pmc.ncbi.nlm.nih.gov/articles/PMC11380450/ serotonine in the context of chronic stress disrupts intestinal barrier function via 5HT7 and AMPK PGC1alpha signaling, causing mitochondrial biogenesis problems.
Do you think extra stimulation of 5-HT2A receptors (=>mitobiogenesis) could also explain why psilocybin and LSD are now both reported to increase lifespan?
The cardiac hypertrophy study is mentioned. Mitochondrial function is the determinant of electrolyte handling which is the determinant of heart rhythm. Almost all arrhythmia is either a dietary deficiency or sweat/urine -induced electrolyte deficiency or a deficiency of energy to handle electrolytes properly.
Chris prior to me taking an ssri and benzo I had no heart issues, once I went on them 3 months into it and on 2 years and slowly tapered off I developed heart arrhythmias and heart block. Off 11 years and still get the arrhythmias. So I’m thinking the drugs caused damage to the electrical system of the heart?
I reached out to you here on Substack at the end of last year regarding picking up with the $999.99 USD value consultation I had left over in the package I purchased from you. You sent me a link to book in on your calendar but I was unable to do this promptly as I had a series of medical emergencies through Christmas and start of the year that required emergency treatment. I emailed in February and May of this year but have not had any reply. The link you sent me doesn't show any available dates for consultation. Please can you advise me what to do?
Hi Chris, it would be interesting to know if, given the speem producing cells are using serotonin, whether frequent ejaculation could cause serotonin insufficiency elsewhere in the body.
I would really like to know if people heal once off. And what is required. Thank you for this discussion on ssris. This all makes sense to me
Good stuff Chris
Absolutely fascinating deep dive into mitochondrial’s many functions. Mitome looks to be a very personalized tool in understanding our own unique physiology. I’ve been an elite athlete for most of my 68 years and have used bio impedance testing on myself and with clients. Always found it hilarious that these tests repeatedly identified my “mitochondrial age” to be TWELVE when I was chronologically 65! I’m still an extremely lean, muscular lady requiring an enormous amount of calories. Mitome may provide some answers. 🤷🏼♀️ Thank you!
Hi Chris! Thank you for the deep dive into serotonine! I am very much interested in perioheral actions if serotonine, which seems to be very complex. In the study https://pmc.ncbi.nlm.nih.gov/articles/PMC11380450/ serotonine in the context of chronic stress disrupts intestinal barrier function via 5HT7 and AMPK PGC1alpha signaling, causing mitochondrial biogenesis problems.
Do you think extra stimulation of 5-HT2A receptors (=>mitobiogenesis) could also explain why psilocybin and LSD are now both reported to increase lifespan?
How does this affect the heart muscle? And how does if cause arrythmias?
The cardiac hypertrophy study is mentioned. Mitochondrial function is the determinant of electrolyte handling which is the determinant of heart rhythm. Almost all arrhythmia is either a dietary deficiency or sweat/urine -induced electrolyte deficiency or a deficiency of energy to handle electrolytes properly.
Chris prior to me taking an ssri and benzo I had no heart issues, once I went on them 3 months into it and on 2 years and slowly tapered off I developed heart arrhythmias and heart block. Off 11 years and still get the arrhythmias. So I’m thinking the drugs caused damage to the electrical system of the heart?
How does one heal the deficiency of energy to handle electrolytes properly
Hi Chris,
I reached out to you here on Substack at the end of last year regarding picking up with the $999.99 USD value consultation I had left over in the package I purchased from you. You sent me a link to book in on your calendar but I was unable to do this promptly as I had a series of medical emergencies through Christmas and start of the year that required emergency treatment. I emailed in February and May of this year but have not had any reply. The link you sent me doesn't show any available dates for consultation. Please can you advise me what to do?
Best wishes,
Sam
Hi Chris, it would be interesting to know if, given the speem producing cells are using serotonin, whether frequent ejaculation could cause serotonin insufficiency elsewhere in the body.
Since serotonin is produced with sunlight exposure, does this mean sunlight exposure leads to increased ATP production?