I tried green lentils (molybdenum) for the first time in my life this past week (I’m an adult). Felt euphoric the first day and still good the next. I’ve been eating lots of protein for the past few years. Thanks for the tip!
I just recently read a paper where threonine restriction alone was significant in stimulating ...hepatoprotectivity. Also tryptophan. BUT again, MOUSE study. You seem confident that the biochemical explanation is sufficiently analogous to the human...but I notice you didn't make any qualifying remarks about how well the results actually would translate. In fact, you seem to cast doubt that methionine restriction per se is of any value! I guess I still have a lot of reading ahead of me on this subject, b/c that's news to me
Would you expect the release of cystine from body tissues to lead to muscle wasting if the high demand for glutathione was chronic or acutely elevated?
If so, could that also elevate glutamate levels, further exacerbating high glutamate levels from the production of S-sulfocysteine?
This reminds me a study where they looked at how eating pure carbs (like sweet coffee or cookies or bread) in the morning would be the worst idea, or the worst idea after any fasting period, and probably why the cartilage and joints in elderly are destroyed - it's obviously better to just continue fasting and break down your bodily cysteine:
"A 3‐h continuation of fasting caused a marked reduction in serum sulphate levels, whereas ingestion of 75 g of glucose in the absence of protein resulted in doubling the reduction.
This suggests that fasting and ingestion of protein‐free calories may produce periods of chondroitin undersulphation that could affect osteoarthritis." -
Chris, do you think the reason the FMD pulled the most homocysteine out of the methylation pathway and into the transsulfuration pathway is because it created a greater need for glutathione because of increased oxidative stress? If so, can you speculate on why there was greater ox.stress?
Really great, thanks. Other than keeping molybdenum status good and overall energy intake balanced, are there other ways to reduce S-sulfocysteine? I’m also wondering about if there’s a link between S-sulfocysteine and glycine? Thanks again
I tried green lentils (molybdenum) for the first time in my life this past week (I’m an adult). Felt euphoric the first day and still good the next. I’ve been eating lots of protein for the past few years. Thanks for the tip!
I just recently read a paper where threonine restriction alone was significant in stimulating ...hepatoprotectivity. Also tryptophan. BUT again, MOUSE study. You seem confident that the biochemical explanation is sufficiently analogous to the human...but I notice you didn't make any qualifying remarks about how well the results actually would translate. In fact, you seem to cast doubt that methionine restriction per se is of any value! I guess I still have a lot of reading ahead of me on this subject, b/c that's news to me
Would you expect the release of cystine from body tissues to lead to muscle wasting if the high demand for glutathione was chronic or acutely elevated?
If so, could that also elevate glutamate levels, further exacerbating high glutamate levels from the production of S-sulfocysteine?
This reminds me a study where they looked at how eating pure carbs (like sweet coffee or cookies or bread) in the morning would be the worst idea, or the worst idea after any fasting period, and probably why the cartilage and joints in elderly are destroyed - it's obviously better to just continue fasting and break down your bodily cysteine:
"A 3‐h continuation of fasting caused a marked reduction in serum sulphate levels, whereas ingestion of 75 g of glucose in the absence of protein resulted in doubling the reduction.
This suggests that fasting and ingestion of protein‐free calories may produce periods of chondroitin undersulphation that could affect osteoarthritis." -
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1798290/
Chris, do you think the reason the FMD pulled the most homocysteine out of the methylation pathway and into the transsulfuration pathway is because it created a greater need for glutathione because of increased oxidative stress? If so, can you speculate on why there was greater ox.stress?
Really great, thanks. Other than keeping molybdenum status good and overall energy intake balanced, are there other ways to reduce S-sulfocysteine? I’m also wondering about if there’s a link between S-sulfocysteine and glycine? Thanks again
Beste Chris, wat kost een lidmaatschap?
En is praktisch vanuit Nederland?
Thanks,
Kind regards,
Patricia