Interestingly methylsulfonylmethane (msm, raises sulfur in the body so different to the sulfite you mentioned) has a nice effect on helping lower allergy symptoms in humans,
So thankful for your work on sulphur / sulphite metabolism . I suffer hugely with reactions to less than 10ppm. I have found that Seeking Health's Histamine Block Plus, which contains 10mg of Riboflavin (plus other things including DAO) does help reduce my symptoms along with 450 mcg Mozyme Forte and 600mg bismuth sub-nitrate. Even then if I don't catch the reaction early enough, I'm into heavy duty antihistamines to stop it.
This one is fascinating and I will probably try to experiment.
My own anecdote which may or may not relate: I haven't had significant seasonal allergies in a couple of decades, but that appeared to clear up when I experimented with high dose Pantothenic acid and Vitamin C. I may have to do two experiments. There's plenty of hay being harvested near where I am now so I can test the 2+2=4.
I just saw a family on Instagram whose little son has a very rare genetic disorder called Mitchell's syndrome. It is caused by a mutation on the ACOX1 gene and it has just recently been discovered that one of the things that helps slow down the progression of the disease is Riboflavin. So interesting!
Chris, can you please put together a release about the health improvements of those on your bioopt health program. As someone on the waiting list with chronic health issues this would provide much needed hope. I do appreciate how scarce your time is while scaling it.
We had to cancel our planned day 2 promotion because we got overwhelmed with demand, so we are working on scaling our capacity before promoting the program. But yes I hear you.
Wow! This is great info and tracks with what I’m seeing in my family. MTHFR was hot 10-15 years ago but no one really talks about it anymore. I have the “mild version” with all the severe symptoms in myself and my siblings and parents. (Brain cancer, Alzheimer’s) My husband has the “severe version”
Not sure if that’s a rabbit hole you’ve been down but I can say emphatically the science isn’t settled on MTHFR. Australia actually has good info on it surprisingly. It seems they take it more seriously than we do.
I have recently started heavy molybdenum supplementation to fight poor sleep. I have ended with asthma resurfacing. Could molybdenum be somehow "mobilising" inactive sulfur causing paradoxical reaction?
I take very high amounts of molybdenum for sulfur bottlenecking related to poor tolerance for methylated vitamins. I read somewhere that tart cherry extract helps with uric acid - I buy NOW brand. No issues so far that I know of.
Thanks for this info. Any idea when your Understanding Sulphur article will be released? Trying hard to connect the dots but I think I need that primer to really get there.
This is interesting. I (as well as my father) struggle with allergic symptoms such as sneezing and a runny nose. I get it once or twice a month. I have tested for lots of potential allergies, but all have come back negative. I have in other words no idea why I get this allergic symptoms. Could it be due to a lack of riboflavin?
Thank you for this Chris. Riboflavin seems to help my sulphur intolerance. But only in small amounts. How much copper from food would you recommend as I’m needing to take 500mcg of molybdenum daily. I’m eating 1oz of liver per day so roughly getting about 4mg through diet and was wondering if this okay?
I don't think there is an intrinsic need for copper with molybdenum. Better to measure copper levels. Mine haven't budged on months of 600 mcg molybdenum.
My PCP recommended methylfolate and methylated B12 last year due to MTHFR. Within 2 weeks, I developed severe joint pain, insomnia, "histamine dump" symptoms at night, and thought I had developed histamine overload. She referred me to a functional medicine doc, who saw that I have +/- COMT and also diagnosed it as issue with my sulfur pathway getting bottlenecked by the methylfolate. I have been taking multiple supplements for a year now, including molybdenum, Riboflavin 5-phosphate, P5P, Seeking Health B complex methyl-free with folinic acid, Magnesium threonate, GABA, ketotifen for possible MCAS, and nystatin for my off-the-chart candida. I did have improvement over the months, I was able to reintegrate sulfur containing foods but only as long as I took high amounts of molybdenum to sleep at night (4,000-6,000mcg). I have recently plateaued. To make it worse, as I started on HRT, my sulfur issues worsened. Last night I had to take > 10,000 mcg of molybdenum to get 4-5 hrs of sleep. I am waiting to hear back from my doc. I read the sulfur protocol as well as the MTHFR protocol. I am sharing the info with her, but I think she is learning along with me. Any thoughts on where to start? I have a sensation in my chest, like butterflies, or anxiety without the mental anxiety, which used to resolve if I took enough molybdenum (until the next night when it would start all over again). Last night, I could not resolve that feeling. I feel like there is something I should be taking, or removing from my arsenal of supplements. She had me take TMG this past year, which I took until last week, but I recently removed it after reading the Sulfur protocol in an effort to see if it helped. I seemed to feel a little better for 2 days, but after last night, I wonder if it was helping me?
Hi Chris! I was looking for a way to sign up for your wait-list to work with you on this sulfur issue. It seems like the page has been taken down. Does that have to do with the BioOpt thing I've been seeing in the comments? Are you currently working with people one-on-one?
Would you please list the Ethe1 snps(RS numbers) of concern? I am not able to find the rs numbers mentioned on the internet that are considered pathogenic/likely pathogenetic in any of my genetic reports. Thank you.
We love riboflavin for a number of reasons. However it seems to stress the kidneys in some way? Causing pee urgency and such overtime? Have you looked into reasons why kidneys get stressed?
Interestingly methylsulfonylmethane (msm, raises sulfur in the body so different to the sulfite you mentioned) has a nice effect on helping lower allergy symptoms in humans,
good results
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293242/
(more health finds on my substack btw)
So thankful for your work on sulphur / sulphite metabolism . I suffer hugely with reactions to less than 10ppm. I have found that Seeking Health's Histamine Block Plus, which contains 10mg of Riboflavin (plus other things including DAO) does help reduce my symptoms along with 450 mcg Mozyme Forte and 600mg bismuth sub-nitrate. Even then if I don't catch the reaction early enough, I'm into heavy duty antihistamines to stop it.
This one is fascinating and I will probably try to experiment.
My own anecdote which may or may not relate: I haven't had significant seasonal allergies in a couple of decades, but that appeared to clear up when I experimented with high dose Pantothenic acid and Vitamin C. I may have to do two experiments. There's plenty of hay being harvested near where I am now so I can test the 2+2=4.
Thank you.
Gosh this is great info! For the last 60 years I've suspected my issues have been sulfur and mercury related. My mom had issues too! Thank you, Chris!
I just saw a family on Instagram whose little son has a very rare genetic disorder called Mitchell's syndrome. It is caused by a mutation on the ACOX1 gene and it has just recently been discovered that one of the things that helps slow down the progression of the disease is Riboflavin. So interesting!
As per allergies and B2: I have just found
https://www.sciencedirect.com/science/article/pii/S0753332224001598
which states that UV-treated B2 drops IG levels
Chris, can you please put together a release about the health improvements of those on your bioopt health program. As someone on the waiting list with chronic health issues this would provide much needed hope. I do appreciate how scarce your time is while scaling it.
Thanks,
Kerr
We had to cancel our planned day 2 promotion because we got overwhelmed with demand, so we are working on scaling our capacity before promoting the program. But yes I hear you.
Thank you I appreciate your reply and everything that you put out. All the best
Wow! This is great info and tracks with what I’m seeing in my family. MTHFR was hot 10-15 years ago but no one really talks about it anymore. I have the “mild version” with all the severe symptoms in myself and my siblings and parents. (Brain cancer, Alzheimer’s) My husband has the “severe version”
Not sure if that’s a rabbit hole you’ve been down but I can say emphatically the science isn’t settled on MTHFR. Australia actually has good info on it surprisingly. It seems they take it more seriously than we do.
My MTHFR Protocol is in the Protocols section :)
I have recently started heavy molybdenum supplementation to fight poor sleep. I have ended with asthma resurfacing. Could molybdenum be somehow "mobilising" inactive sulfur causing paradoxical reaction?
My guess is it's related to a rise in uric acid:
https://onlinelibrary.wiley.com/doi/abs/10.1111/all.14310
Then what should be done if you think you need molybdenum but also have high uric acid?
Decrease anything that increases breakdown of AMP or caffeine.
I take very high amounts of molybdenum for sulfur bottlenecking related to poor tolerance for methylated vitamins. I read somewhere that tart cherry extract helps with uric acid - I buy NOW brand. No issues so far that I know of.
Thanks for this info. Any idea when your Understanding Sulphur article will be released? Trying hard to connect the dots but I think I need that primer to really get there.
Hopefully this week!
Still waiting! One week has turned into seven ☹️ Any updates on the release of Understanding Sulphur? Thx!
This is interesting. I (as well as my father) struggle with allergic symptoms such as sneezing and a runny nose. I get it once or twice a month. I have tested for lots of potential allergies, but all have come back negative. I have in other words no idea why I get this allergic symptoms. Could it be due to a lack of riboflavin?
It could be due to anything impacting sulfur metabolism, which is covered in the Sulfur Protocol. (Not, of course, to the exclusion of other causes.)
Thank you for this Chris. Riboflavin seems to help my sulphur intolerance. But only in small amounts. How much copper from food would you recommend as I’m needing to take 500mcg of molybdenum daily. I’m eating 1oz of liver per day so roughly getting about 4mg through diet and was wondering if this okay?
I don't think there is an intrinsic need for copper with molybdenum. Better to measure copper levels. Mine haven't budged on months of 600 mcg molybdenum.
Thank you, appreciate it.
My PCP recommended methylfolate and methylated B12 last year due to MTHFR. Within 2 weeks, I developed severe joint pain, insomnia, "histamine dump" symptoms at night, and thought I had developed histamine overload. She referred me to a functional medicine doc, who saw that I have +/- COMT and also diagnosed it as issue with my sulfur pathway getting bottlenecked by the methylfolate. I have been taking multiple supplements for a year now, including molybdenum, Riboflavin 5-phosphate, P5P, Seeking Health B complex methyl-free with folinic acid, Magnesium threonate, GABA, ketotifen for possible MCAS, and nystatin for my off-the-chart candida. I did have improvement over the months, I was able to reintegrate sulfur containing foods but only as long as I took high amounts of molybdenum to sleep at night (4,000-6,000mcg). I have recently plateaued. To make it worse, as I started on HRT, my sulfur issues worsened. Last night I had to take > 10,000 mcg of molybdenum to get 4-5 hrs of sleep. I am waiting to hear back from my doc. I read the sulfur protocol as well as the MTHFR protocol. I am sharing the info with her, but I think she is learning along with me. Any thoughts on where to start? I have a sensation in my chest, like butterflies, or anxiety without the mental anxiety, which used to resolve if I took enough molybdenum (until the next night when it would start all over again). Last night, I could not resolve that feeling. I feel like there is something I should be taking, or removing from my arsenal of supplements. She had me take TMG this past year, which I took until last week, but I recently removed it after reading the Sulfur protocol in an effort to see if it helped. I seemed to feel a little better for 2 days, but after last night, I wonder if it was helping me?
Hi Chris! I was looking for a way to sign up for your wait-list to work with you on this sulfur issue. It seems like the page has been taken down. Does that have to do with the BioOpt thing I've been seeing in the comments? Are you currently working with people one-on-one?
Here’s the BioOpt waitlist: https://www.bioopthealth.com/
Hi Chris,
Would you please list the Ethe1 snps(RS numbers) of concern? I am not able to find the rs numbers mentioned on the internet that are considered pathogenic/likely pathogenetic in any of my genetic reports. Thank you.
We love riboflavin for a number of reasons. However it seems to stress the kidneys in some way? Causing pee urgency and such overtime? Have you looked into reasons why kidneys get stressed?
Not obvious this is "stress" rather than getting rid of the extra riboflavin.