Can confirm TMG does same. Anything I can replace it with as a donor when combining with NR? I already take creatine and glycine not sure if that’s enough.
Then it’s highly likely it’s an effect of methylation itself. Probably shouldn’t take it and would be helpful to run. Genova Methylation Panel, especially while on it for a short period of tolerable.
Any idea why all forms of choline cause depression/lethargy and brain fog for me? I’ve tried sunflower lecithin, alpha GPC etc. Is “choline depression” real or just some error in energy metabolism?
Could be overmethylation, hyperammonemia, or something more specific to choline. Would be helpful to test it against TMG, which if it doesn’t cause the same problem, rules out an effect vis methylation and transsulfuration.
Can confirm TMG does same. Anything I can replace it with as a donor when combining with NR? I already take creatine and glycine not sure if that’s enough.
Then it’s highly likely it’s an effect of methylation itself. Probably shouldn’t take it and would be helpful to run. Genova Methylation Panel, especially while on it for a short period of tolerable.
Thank you. Hoping to compile full bloodwork shortly to book consultation and will include that
Sounds good.
Any idea why all forms of choline cause depression/lethargy and brain fog for me? I’ve tried sunflower lecithin, alpha GPC etc. Is “choline depression” real or just some error in energy metabolism?
Could be overmethylation, hyperammonemia, or something more specific to choline. Would be helpful to test it against TMG, which if it doesn’t cause the same problem, rules out an effect vis methylation and transsulfuration.