Why Would Riboflavin WORSEN a Riboflavin-Dependent Metabolic Defect?
Specifically we look at a short-chain acyl CoA dehydrogenase deficiency with elevated ehthylmalonic acid.
In the comments of Thiamin Supplements: Not For Everyone, Rae asked:
I have short chain acyl coa dehydrogenase deficiency and have been using riboflavin with success. Eventually I plateaued and was still left with terrible symptoms that come and go throughout the day like head pressure, anxiety, rumination and muscle twitching. A practitioner suggested upping my dose of riboflavin to over 800mg which lowered my ethylmalonic acid levels before they went all the way back up to baseline, along with raising pyruvate in urine above normal for the first time ever. Even after stopping the high dose and going back to 100mg riboflavin my urine smells like sulphur sometimes. Is it possible such a high dose of riboflavin interfered with thiamine status? I also have borderline low copper levels.
I am not a doctor, this is not medical advice, Rae is not my patient, but there’s some basic biochemistry that we can dig into to answer Rae’s question.
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