I’ve consistently had low CoQ10 serum levels and haven’t had any other measures assessed. My neurological symptoms usually respond positively to supplementation, but time of administration has a dramatic impact on whether I experience benefits.
In his other CoQ10 articles, Chris mentions that ubiquinol is absorbed about twice as well as ubiquinone on average, i.e. the dose of ubiquinol only needs to be ~50% of the ubiquinone one.
Wow didn't realize CoQ10 testing is such an intricate topic. Sounds like Iron.
I took the Genova panel in January this year and the guidebook explained that people with high HMG Hydroxymethylglutarate have an issue synthesizing enough CoQ10, but even though my HMG was rock bottom the CoQ10 reading was also low at 20%.
Is it safe to presume that because we don't know enough about it we should still try and be in the top half? Or are the blood results so insignificant that it's just not worth looking into until you can prove there are genetic disorders or physical symptoms that call for proper attention?
The HMG thing — I have not read the handbook but I’m just going on what you’re saying — is just a “maybe” of many. You would not know whether it’s mitochondrial HMG, which is unrelated to CoQ10 and involved in leucine catabolism and ketogenesis, or cytosolic, which is a precursor to CoQ10, and there are innumerable other steps in CoQ10 synthesis that if blocked would have no impact on HMG.
Looked into it for the fine print, they say the HMG "can reveal a block". "Can", not "will".
I sent in a full sequencing sample a month ago and cannot wait to look through the results. You've got a great list of codes in that other CoQ10 article summary, I can't say that I expect the sequencing.com output to be as helpful or even intuitive to use but I will find out when it comes in.
I cannot believe you missed that statins lower cholesterol by interfering with the process that manufactures cholesterol and CoQ10 in your body. Therefore if on statins your CoQ10 will likely be low. Or did I miss something.
I’ve consistently had low CoQ10 serum levels and haven’t had any other measures assessed. My neurological symptoms usually respond positively to supplementation, but time of administration has a dramatic impact on whether I experience benefits.
Interesting, what time is beneficial?
This article never mentions the converted form of CoQ10 which is Ubiquinol. I supplement with Ubiquinol only.
It wasn’t relevant to this article, but that is discussed in “the” CoQ10 article:
https://chrismasterjohnphd.substack.com/p/does-coq10-deserve-a-spot-on-your
In his other CoQ10 articles, Chris mentions that ubiquinol is absorbed about twice as well as ubiquinone on average, i.e. the dose of ubiquinol only needs to be ~50% of the ubiquinone one.
Wow didn't realize CoQ10 testing is such an intricate topic. Sounds like Iron.
I took the Genova panel in January this year and the guidebook explained that people with high HMG Hydroxymethylglutarate have an issue synthesizing enough CoQ10, but even though my HMG was rock bottom the CoQ10 reading was also low at 20%.
Is it safe to presume that because we don't know enough about it we should still try and be in the top half? Or are the blood results so insignificant that it's just not worth looking into until you can prove there are genetic disorders or physical symptoms that call for proper attention?
See the CoQ10 article short answer.
The HMG thing — I have not read the handbook but I’m just going on what you’re saying — is just a “maybe” of many. You would not know whether it’s mitochondrial HMG, which is unrelated to CoQ10 and involved in leucine catabolism and ketogenesis, or cytosolic, which is a precursor to CoQ10, and there are innumerable other steps in CoQ10 synthesis that if blocked would have no impact on HMG.
Thanks Chris,
Looked into it for the fine print, they say the HMG "can reveal a block". "Can", not "will".
I sent in a full sequencing sample a month ago and cannot wait to look through the results. You've got a great list of codes in that other CoQ10 article summary, I can't say that I expect the sequencing.com output to be as helpful or even intuitive to use but I will find out when it comes in.
I cannot believe you missed that statins lower cholesterol by interfering with the process that manufactures cholesterol and CoQ10 in your body. Therefore if on statins your CoQ10 will likely be low. Or did I miss something.
George
Please review the CoQ10 article before concluding I missed something.
https://chrismasterjohnphd.substack.com/p/does-coq10-deserve-a-spot-on-your
It's covered several times in the article on whether you should be taking CoQ10.