What Makes a Good Marker of Nutritional Status?
In this special interlude, I lay down the framework of the five core principles that make a good marker of nutritional status. This is to lay down the framework for a series of podcasts in the future about managing nutritional status for specific vitamins and minerals.
Since these core principles will be referred back to as a general reference in so many other episodes, this one has a special place outside of the sequence and you can reach it at any time with this url:
The episodes of the series are kept in the show notes section, under Episodes of the Managing Nutritional Status Series.
In this episode, you’ll find all of the following and more:
00:37 Cliff Notes
02:44 Purpose of this podcast and its place in the upcoming series on managing nutritional status
05:13 What are the core principles?
05:25 Principle #1: We understand its biochemistry and physiology.
08:22 Principle #2: It has been validated against changes in nutritional status.
10:35 Principle #3: Sensitivity
11:10 Principle #4 Specificity
13:01 Principle #5: It must be interpreted in the overall context of other markers and the clinical and health history, current signs and symptoms, and diet and lifestyle analysis.
16:34 Example of principle #1: Spectracell vs dp-ucMGP as tests of vitamin K2 status.
20:38 Example of principle #2: 25(OH)D vs. calcitriol
22:37 Example of principle #3: transferrin saturation vs. ferritin
24:26 Example of principle #4: specificity of 25(OH)D and contexts where its specificity fails
26:08 Example of principle #5: distinguishing between calcium and vitamin D deficiencies as causes of 25(OH)D by testing PTH, calcitriol, and analyzing the diet and lifestyle
31:08 Shotgun approaches to nutritional testing
33:49 Whether to act on leads from shotgun approaches should depend on the risks and other costs of the actions.
Episodes of the Managing Nutritional Status Series
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