I love these lessons. I would love to see a section on the effects of environmental conditions on nutrients. Does storage lower nutrients? Does cooking destroy the nutrients? exposure to light? etc..
I'd need your brains, please. If someone suffers from depression and recently reports ravenous appetite, body fat increases and most likely water retention from general overloading (high stress plus intensive workouts) but at the same time is reporting postprandial hypoglycemia shortly after a load of carbs, could that indicate thiamin deficiency?
Okay, interesting. So, say you have just enough thiamin in your diet, and you have just enough thiamin in your body to process the amount of carbs in your diet. But say you then incorporate a bunch of white rice into your diet for a few months, otherwise keeping the thiamin content of your diet the same. At the end of a few months you check your thiamin status again. It won't be depleted, right? It's not like the empty carbs use up your body's reserves of thiamin. It's just that while you are eating the white rice you probably won't feel very good because you won't have enough thiamin to process it. But once you drop the thiamin-deficient white rice, and you go back to eating your normal diet, it's not like you will need to build up your thiamin status again. You should be back up to speed as soon as you drop the white rice. Is this right?
You could see it "depleted," depending on what you are looking at, but what I'm saying is you haven't actually "depleted" it if you moved it all into newly synthesized pyruvate dehydrogenase. You have simply put it to good use.
Sure. It's easiest if I provide the following link (different to the link above). Georgi lists about 20 papers. I have no expectation that you check them all out, was simply curious if you had any intuitions about it.
Prosult is a compound found in garlic apparently, and he seems to think that it might be able to have similar effects to Hcl, but at lower doses.
Well, for now I can say this. Previously when I looked at claims for any of these thiamin isoforms, there were no head to head comparisons, and I was not impressed by anything except that people should self-experiment with them to see if they get better results.
Giving you a better answer than that would require some research.
If you want me to look into it I recommend submitting this for the AMA contest, the deadline for which is midnight tonight.
I love these lessons. I would love to see a section on the effects of environmental conditions on nutrients. Does storage lower nutrients? Does cooking destroy the nutrients? exposure to light? etc..
Yes that will definitely be in the book!
This should probably be updated given your recent article "Thiamin Supplements Not for Everyone" https://chrismasterjohnphd.substack.com/p/thiamin-supplements-not-for-everyone
Thanks, I will need to update all the V&M101 material but it will be a consolidated overhaul at a specific time not piecemeal updates.
I'd need your brains, please. If someone suffers from depression and recently reports ravenous appetite, body fat increases and most likely water retention from general overloading (high stress plus intensive workouts) but at the same time is reporting postprandial hypoglycemia shortly after a load of carbs, could that indicate thiamin deficiency?
No, I would think thiamin deficiency would lead to hyperglycemia. This person sounds like they need to eat way more food and stop working out so hard.
You say that "Eating carbs won't deplete your thiamin."
However, what do you think about these two articles?
https://pubmed.ncbi.nlm.nih.gov/11582856/
https://pubmed.ncbi.nlm.nih.gov/15439145/
Carbs absolutely increase the thiamin requirement. This isn't "depletion."
Okay, interesting. So, say you have just enough thiamin in your diet, and you have just enough thiamin in your body to process the amount of carbs in your diet. But say you then incorporate a bunch of white rice into your diet for a few months, otherwise keeping the thiamin content of your diet the same. At the end of a few months you check your thiamin status again. It won't be depleted, right? It's not like the empty carbs use up your body's reserves of thiamin. It's just that while you are eating the white rice you probably won't feel very good because you won't have enough thiamin to process it. But once you drop the thiamin-deficient white rice, and you go back to eating your normal diet, it's not like you will need to build up your thiamin status again. You should be back up to speed as soon as you drop the white rice. Is this right?
You could see it "depleted," depending on what you are looking at, but what I'm saying is you haven't actually "depleted" it if you moved it all into newly synthesized pyruvate dehydrogenase. You have simply put it to good use.
Georgi Dinkov from Idea Labs recently launched an updated B vitamin supplement called Energin (https://raypeatforum.com/community/threads/energin-liquid-b-complex-vitamin-mix.3859/). The update was to replace the Thiamine Hcl portion to Prosultiamine. Ignoring the other b vitamins in the supplement, do you any thoughts on that variation?
I’m not familiar with prosultiamine. Can you post a study that justifies the rationale for it?
Sure. It's easiest if I provide the following link (different to the link above). Georgi lists about 20 papers. I have no expectation that you check them all out, was simply curious if you had any intuitions about it.
Prosult is a compound found in garlic apparently, and he seems to think that it might be able to have similar effects to Hcl, but at lower doses.
https://raypeatforum.com/community/threads/psa-change-in-energin-formulation-thiamine-replaced-by-prosultiamine.48135/
Well, for now I can say this. Previously when I looked at claims for any of these thiamin isoforms, there were no head to head comparisons, and I was not impressed by anything except that people should self-experiment with them to see if they get better results.
Giving you a better answer than that would require some research.
If you want me to look into it I recommend submitting this for the AMA contest, the deadline for which is midnight tonight.