The Science Behind The Depression Protocol

Hundreds of randomized controlled trials show that non-drug approaches are superior to drugs. Here's the evidence.

The Depression Protocol contains the practical how-tos to beat depression without SSRIs or other drugs.

This article explains the scientific rationale behind it.

Principally, it is based on hundreds of randomized controlled trials of psychotherapy, exercise, and 44 different nutritional supplements.

This body of literature has twelve times as many trials and five times as many participants as the placebo-controlled SSRI trial literature, and the effect sizes are larger, in most cases the risk of publication bias is no larger, and the nature of these strategies allows many of them to be safely combined for better results, whereas doing so with drugs just increases the risk of serious side effects.

It also refers to trial literature for other non-drug approaches such as repetitive transcranial stimulation and electroconvulsive therapy, though not everything makes the cut.

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