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I am 1 year in on mold illness/CIRS treatment and am doing much better after being so very sick for 6 years. I am now addressing high homocysteine and realize I am very intolerant to methyl donors. I've tried a small dose of a variety of things but always by day 3 or 4 I have severe reaction/unwellness, head pressure, extreme aching, exhaustion - like a severe immune reaction! I am wanting to know if others who are intolerant have these symptoms. I do have COMT and A1298C and C1667 - so that is working against me. I am seeing a top geneticist in 2 weeks and working with Cleveland Clinic Functional Med on mold/CIRS. My reaction/intolerance scares me it is so bad and wondered if I am the only one who has such a physical reaction and not so much mental. I would be very grateful for your insight on this as I try to figure out what direction I should go. Also do you do web consultations?
Thank you very much for your response. Your videos are excellent and have been very helpful as I learn more about methylation. The geneticist I see told me today genetics show why this is happening to me and helping me fix it. Mold/CIRS and methylation - this has been such a journey!
Are there any differences in the nutrient/actionable remedies for methylation between having MTHFR and COMT? In other words, should someone dealing with low COMT (due to COMT ++ met/met) look at the same exact methylation recommendations as for your advice about MTHFR, or might there be different considerations for COMT? (Because both require methylation). Thank you.
In regard to "313: Phosphatidylcholine and TMAO", I'd like to see your thoughts on this 2020 article: "Trimethylamine N-Oxide in Relation to Cardiometabolic Health--Cause or Effect?" C. Papandreou, M. Moré & A. Bellamine, _nutrients_ 2020 12(5), 1330 -- https://www.mdpi.com/2072-6643/12/5/1330
For things that require reading papers, the best thing to do is submit it to a Masterpass Q&A question submission contest with some question attached to it.
I am 1 year in on mold illness/CIRS treatment and am doing much better after being so very sick for 6 years. I am now addressing high homocysteine and realize I am very intolerant to methyl donors. I've tried a small dose of a variety of things but always by day 3 or 4 I have severe reaction/unwellness, head pressure, extreme aching, exhaustion - like a severe immune reaction! I am wanting to know if others who are intolerant have these symptoms. I do have COMT and A1298C and C1667 - so that is working against me. I am seeing a top geneticist in 2 weeks and working with Cleveland Clinic Functional Med on mold/CIRS. My reaction/intolerance scares me it is so bad and wondered if I am the only one who has such a physical reaction and not so much mental. I would be very grateful for your insight on this as I try to figure out what direction I should go. Also do you do web consultations?
I would say this is not common but you are far from the only one.
Thank you very much for your response. Your videos are excellent and have been very helpful as I learn more about methylation. The geneticist I see told me today genetics show why this is happening to me and helping me fix it. Mold/CIRS and methylation - this has been such a journey!
Are there any differences in the nutrient/actionable remedies for methylation between having MTHFR and COMT? In other words, should someone dealing with low COMT (due to COMT ++ met/met) look at the same exact methylation recommendations as for your advice about MTHFR, or might there be different considerations for COMT? (Because both require methylation). Thank you.
I would use the MTHFR protocol, I don't believe in "treating" COMT.
In regard to "313: Phosphatidylcholine and TMAO", I'd like to see your thoughts on this 2020 article: "Trimethylamine N-Oxide in Relation to Cardiometabolic Health--Cause or Effect?" C. Papandreou, M. Moré & A. Bellamine, _nutrients_ 2020 12(5), 1330 -- https://www.mdpi.com/2072-6643/12/5/1330
For things that require reading papers, the best thing to do is submit it to a Masterpass Q&A question submission contest with some question attached to it.