Enjoyed reading this article… one thought I might share…
If you have a fatty liver .. your chances of burning fat are compromised…. most people ingesting high corn fructose have fatty livers because the liver does not process HCF so stores it within its own organ to protect the body.. and the only way out of the mess seems to be inositol and choline… the liver loves sulphur … by way of glutathione … which also detoxes those unwanted toxins…. reduce fatty liver is possible which in turn helps you lose weigh because the pancreas load is reduced.
FOTI fat outside thin inside have enough inulin in their diet but the group TOFI thin outside fat inside do not … Dr Robert Lustig makes good points in his book “Metabolical”… thankyou for all the work you do to bring explained understanding.
Do you think H2S produced by certain types of gut bacteria might be a significant factor in this balance? It seems like the microbiome-derived H2S does diffuse out of the gut into the circulation: https://asm.org/articles/2023/october/hydrogen-sulfide-gut
Yes it could play a role in certain conditions, but as I've written about I think endogenous clearance is more relevant than the microbiome in most cases.
"That is, for a given excess energy intake, one has two paths: with greater H2S, one becomes fatter and less likely to become diabetic; with less H2S, one becomes less fat but more likely to become diabetic. "
This seems to contradict what you say in the top subheading which is the common understanding that obesity strongly predisposes to t2dm.
No it does not contradict it at all. I would recommend reading the rest of the article over and over until you get it, or listening to the podcast I linked to if you need more information.
I have no reason to think that is the case. If it is, you can explain to me exactly what I said that was confusing and how it could have been stated better. If you cannot do that, then the problem is likely with the effort you are willing to expend or your ability to handle nuance.
What a gem of an insight, such a simple mechanism but potentially so important. Thanks for the text Chris!
That picture alone should help motivate people to lose weight!
Enjoyed reading this article… one thought I might share…
If you have a fatty liver .. your chances of burning fat are compromised…. most people ingesting high corn fructose have fatty livers because the liver does not process HCF so stores it within its own organ to protect the body.. and the only way out of the mess seems to be inositol and choline… the liver loves sulphur … by way of glutathione … which also detoxes those unwanted toxins…. reduce fatty liver is possible which in turn helps you lose weigh because the pancreas load is reduced.
FOTI fat outside thin inside have enough inulin in their diet but the group TOFI thin outside fat inside do not … Dr Robert Lustig makes good points in his book “Metabolical”… thankyou for all the work you do to bring explained understanding.
Obesity is incredibly strongly tied to fatty liver, and obese people lose weight all the time. I do not think that fatty liver prevents fat oxidation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7056545/
Do you think H2S produced by certain types of gut bacteria might be a significant factor in this balance? It seems like the microbiome-derived H2S does diffuse out of the gut into the circulation: https://asm.org/articles/2023/october/hydrogen-sulfide-gut
Yes it could play a role in certain conditions, but as I've written about I think endogenous clearance is more relevant than the microbiome in most cases.
I don't understand what you are saying:
"That is, for a given excess energy intake, one has two paths: with greater H2S, one becomes fatter and less likely to become diabetic; with less H2S, one becomes less fat but more likely to become diabetic. "
This seems to contradict what you say in the top subheading which is the common understanding that obesity strongly predisposes to t2dm.
No it does not contradict it at all. I would recommend reading the rest of the article over and over until you get it, or listening to the podcast I linked to if you need more information.
You need an editor in that case.
I have no reason to think that is the case. If it is, you can explain to me exactly what I said that was confusing and how it could have been stated better. If you cannot do that, then the problem is likely with the effort you are willing to expend or your ability to handle nuance.
I exactly did that already and it seems you aren't able to understand
https://chrismasterjohnphd.substack.com/p/erythritol-and-blood-clotting?utm_source=publication-search