Hi Chris, One version of this article, you must have edited off the last paragraph that included a link to your mitochondria testing lab; mito.me. I dabble in anti-aging, can/do take TOO much turning into counter-productivity. In the mitocondria space, uber-health coaches like Alex Kikel (search youtube on Alex Kikel peptides), he talks about boosting/multiplying mitochondria, thus I've experimented with SLU-PP-332. SS-31, MOTSC, urolithin-a, spermadine, then the typical CoQ10, PQQ. Per Alex Kikel, one can stack too many mito boosters and get over stimulation. Symptoms per him a bit like hyper-thyroid, energized but a bit jittery hard to focus. His tip is to back off the mito stack in this scenario.
Is the mito.me test quantitative? IE give a quantity of mitochondria, vitality/functionality? IE 0-100% of optimal?
It seems the mitochondria in the STD American are so poorly functioning a stack of ALL of the above is beneficial. In a top performing athlete the above stack sends their mito over the peak, as it seems for me. IE No good info on if urolithin-a (et al) has a benefit for YOUR mitochondria?
I suspect I'm talking myself into just following Kikel's tip, don't take all of the above all at the same time, but cycle each ONE for 4 weeks, then to the next. Else I'd have to be testing at $750 per tuning, then another mito test. That is if this test is even quantitative + qualitative (vs binary). I'm glad to see mito.me . We need more tests, more data, more measures of bodily function.
I need a calendar based trap door system where I put nutricals I should NOT take and only when the door opens for that 4 week period, its not taken. Yes yes my reply to the just food based advocations are; At over 60yo, and me into my 70's, and interested in therapeutic improvements, then therapeutic doses and compounds are _necessary_. I'm not interested in STD American anything, or average.
Tnx for this SSRI, brain, mitochondria research! Curt
Could there be a connection between taking SSRI and getting Multiple Chemical Sensitivity (MCS)?
I took Sertraline for 3 years and got chronic gastro intenstinal problems from it. Roughly 2 years after stopping the medication I got MCS. Some concider MCS to be a NO/ONOO− Cycle problem.
In my case I had a year of hard work. 60 hour weeks, with 5-6 hours of sleep in the week days (I need 7). I didn't think that I would be able to keep it up for more than another year. At the same time, I had one injured knee, back and lateral epicondylitis, I was never able to rest and heal up (the knee and back, from a stair accident while moving to another city and the tennis elbow injury from lifting a heavy object on the jobb).
Besides this, I was forced to work in a building with water damage and a lot of visible mold (I spent about a half year in that place). And some chemicals (mostly glue fumes and newly printed paper. Not computer printer, but cardboard display cases and other niche products made of newly fabricated corrugated fiberboard).
I got a double dose of Depo-Medrol for the elbow and it was like it was the last drop, that got the cup to overflow. I got it on a Friday and on Monday the following week I was sent to another workplace. A building filled with hundreds of industrial chemicals, that most don't get in contact with (like glue that is only used to fasten windshields in cars. Many people have cars, but then the glue is cured, not in its liquid form).
Anyway, within one hour of being in this new place, I got MCS. That was 10 years ago and the things that I react to, is constantly growing.
Thanks. I will watch it when possible. There is unfortunately a catch 22. I am sensitive to basically everything, including every type of food and supplement (I have survived on pork and yoghurt, for almost 4 years), and my condition have made it impossible to find any work that I can do. Bcause of this I don't have an income to pay someone for consultations.
I am pretty sure that it isn't always the food itself that I react to, sometimes it is how it's been treated (come in contact with) and how it is packaged . The new trend of using recycled materials in food packaging and clothes removed almost all of the last things that I could use.
Thank you. I wish more MDs understood this. I am grateful for your articles.
I’m eager for the next article. Great read.
Hi Dr Chris
In that regard, please can you talk about methylene blue and natural Serotonin modulators like Saffron, Rhodiola, Ginseng, Curcumin etc?
25byears on sertraline. Weaning off now down to 50 from 150 . So far so good, knock on wood
Way heavy for me but extremely interesting!! Thank you Chris
Hi Chris, One version of this article, you must have edited off the last paragraph that included a link to your mitochondria testing lab; mito.me. I dabble in anti-aging, can/do take TOO much turning into counter-productivity. In the mitocondria space, uber-health coaches like Alex Kikel (search youtube on Alex Kikel peptides), he talks about boosting/multiplying mitochondria, thus I've experimented with SLU-PP-332. SS-31, MOTSC, urolithin-a, spermadine, then the typical CoQ10, PQQ. Per Alex Kikel, one can stack too many mito boosters and get over stimulation. Symptoms per him a bit like hyper-thyroid, energized but a bit jittery hard to focus. His tip is to back off the mito stack in this scenario.
Is the mito.me test quantitative? IE give a quantity of mitochondria, vitality/functionality? IE 0-100% of optimal?
It seems the mitochondria in the STD American are so poorly functioning a stack of ALL of the above is beneficial. In a top performing athlete the above stack sends their mito over the peak, as it seems for me. IE No good info on if urolithin-a (et al) has a benefit for YOUR mitochondria?
I suspect I'm talking myself into just following Kikel's tip, don't take all of the above all at the same time, but cycle each ONE for 4 weeks, then to the next. Else I'd have to be testing at $750 per tuning, then another mito test. That is if this test is even quantitative + qualitative (vs binary). I'm glad to see mito.me . We need more tests, more data, more measures of bodily function.
I need a calendar based trap door system where I put nutricals I should NOT take and only when the door opens for that 4 week period, its not taken. Yes yes my reply to the just food based advocations are; At over 60yo, and me into my 70's, and interested in therapeutic improvements, then therapeutic doses and compounds are _necessary_. I'm not interested in STD American anything, or average.
Tnx for this SSRI, brain, mitochondria research! Curt
Chris what is the way out of PSSD from your point of view?
Could there be a connection between taking SSRI and getting Multiple Chemical Sensitivity (MCS)?
I took Sertraline for 3 years and got chronic gastro intenstinal problems from it. Roughly 2 years after stopping the medication I got MCS. Some concider MCS to be a NO/ONOO− Cycle problem.
In my case I had a year of hard work. 60 hour weeks, with 5-6 hours of sleep in the week days (I need 7). I didn't think that I would be able to keep it up for more than another year. At the same time, I had one injured knee, back and lateral epicondylitis, I was never able to rest and heal up (the knee and back, from a stair accident while moving to another city and the tennis elbow injury from lifting a heavy object on the jobb).
Besides this, I was forced to work in a building with water damage and a lot of visible mold (I spent about a half year in that place). And some chemicals (mostly glue fumes and newly printed paper. Not computer printer, but cardboard display cases and other niche products made of newly fabricated corrugated fiberboard).
I got a double dose of Depo-Medrol for the elbow and it was like it was the last drop, that got the cup to overflow. I got it on a Friday and on Monday the following week I was sent to another workplace. A building filled with hundreds of industrial chemicals, that most don't get in contact with (like glue that is only used to fasten windshields in cars. Many people have cars, but then the glue is cured, not in its liquid form).
Anyway, within one hour of being in this new place, I got MCS. That was 10 years ago and the things that I react to, is constantly growing.
Sorry to hear Cane, this channel focuses on whole functional issues like yours. He may do consults. https://www.youtube.com/watch?v=4Sedxm3Nq00
Thanks. I will watch it when possible. There is unfortunately a catch 22. I am sensitive to basically everything, including every type of food and supplement (I have survived on pork and yoghurt, for almost 4 years), and my condition have made it impossible to find any work that I can do. Bcause of this I don't have an income to pay someone for consultations.
I am pretty sure that it isn't always the food itself that I react to, sometimes it is how it's been treated (come in contact with) and how it is packaged . The new trend of using recycled materials in food packaging and clothes removed almost all of the last things that I could use.