I've settled on 50mg nicotinic acid a day for my son (history of Autistic catatonia). I am running a short term 550mg run to see how it affects his behavior. Generally his energy is through the roof.
Dad, 77, has been on 2500mg flush Niacin for 30 months, with remarkable improvement in his cardiovascular issues (carotid artery unblocked, off statins and so much more). His brain also responds very well to MB with that dose.
I got prediabetic from high dose Niacin, but it helps my energy and brain. I use it in short spirts now. It generally helps me think and makes me fat 😢
My whole family line must have varying degrees of electron transport chain issues. Figuring out specific needs has been challenging. I'm very appreciative of this article.
As per the directions, "start by taking one capsule three times per day, gradually increasing to 4 capsules three times per day as one can comfortably acclimate to the flushing effects of Niacin at increasing serving amounts."
That's 3 grams of Niacin a day..... Thats what I'm doing with 6 grams of curcumin.
"If you note the shaded area representing the confidence interval, the sweet spot seems to be just under 50 milligrams a day, because this is where the shaded area dips below the dotted line, indicating a more statistically robust evidence of lower risk."
Why are the uncertainty bars higher for higher mg/day even as the RR goes down? Is it lower sample size?
What's the rational for making it liposomal? I have not encountered that yet! Interested!
Remember, we all have different DNA, and some can tolerate (or need) high doses, while that higher dose can cause severe problems for others. I'm glad that perspective is sprinkled into Masterjohn's review.
Yeah I'm also suspicious of the guy, he seems to be pretty great at Marketing and turning early research into products but we'll really only know in 50-80 years if all that stuff works as advertised.
Thank you Chris. the issue is not high glycine for me. I have low urine glycine., which contributes to salicylate and phenol intolerance. but when I was trying to take glycine-- I got a headache and nausea from it. and I do really well with low dose niacinamide. This is why I wondered if B3 would need to be adequate to handle the glycine.
Well you don't have to live forever, just until you paid back your student loans. As far as NAD+ generation goes is there even a proven advantage of NMN over plain old niacinamide - considering the difference in price?
I've settled on 50mg nicotinic acid a day for my son (history of Autistic catatonia). I am running a short term 550mg run to see how it affects his behavior. Generally his energy is through the roof.
Dad, 77, has been on 2500mg flush Niacin for 30 months, with remarkable improvement in his cardiovascular issues (carotid artery unblocked, off statins and so much more). His brain also responds very well to MB with that dose.
I got prediabetic from high dose Niacin, but it helps my energy and brain. I use it in short spirts now. It generally helps me think and makes me fat 😢
My whole family line must have varying degrees of electron transport chain issues. Figuring out specific needs has been challenging. I'm very appreciative of this article.
I would like to see what Dimity Kats thinks of the paper
😂 general swears and a ton of tweets. It will be fun to read
https://purebulk.com/products/dmitry-kats-gpr109a
N-Acetyl L-Glutamine 382 mg
Niacin 250 mg †
Folic Acid 303.87 mcg
As per the directions, "start by taking one capsule three times per day, gradually increasing to 4 capsules three times per day as one can comfortably acclimate to the flushing effects of Niacin at increasing serving amounts."
That's 3 grams of Niacin a day..... Thats what I'm doing with 6 grams of curcumin.
He keeps changing his protocol. The last one was niacur (as he discussed with Chris) which is a 2 to 1 95% curcumins and Niacin.
On his site...https://www.hom3ostasis.com/protocol/
it's NIACIRON
I'm doing Niacur With high dose Niacin, I'll check my blood work after 30 days.
So far (3 weeks in) no ill effects. Less aches and pains and clearing brain fog. I have cut back on all other supplements for this trial.
"If you note the shaded area representing the confidence interval, the sweet spot seems to be just under 50 milligrams a day, because this is where the shaded area dips below the dotted line, indicating a more statistically robust evidence of lower risk."
Why are the uncertainty bars higher for higher mg/day even as the RR goes down? Is it lower sample size?
I assume so, there are always fewer people with intakes at the extreme.
Wow. “ Niacin (nicotinic acid) supplements that exceed what can be turned into NAD+ are ◾️◾️conjugated to glycine. ”
Is it possible that glycine intolerance or high serum glycine may occur with B3 deficiency ?
I have several friends who have high serum glycine and I’ve seen lots of different explanations for this.
I had low B3 and lots of nasty symptoms that were resolved with 125-250mg (low dose ) niacinamide
then low dose 25 mg inositol hexanicotinate
I also tried to take glycine for salicylate intolerance but gave me a bad headache. Sodium bicarb resolved the headache.
Thank you.
No, I do not think so as this is a means of disposing of excess nicotinic acid, which is not normally appreciable.
Sodium bicarbonate increases salicylate excretion. High glycine could be a glycine cleavage deficiency. Not sure what bicarb would do for that.
Does bicarb increase salicylate excretion because it increases urine alkalinity ?
I think you reported that you used bicarb to improve alkalinity but then realized zinc would be a better choice.
I see a few pubmed articles that suggest zinc help remove salicylates. Here’s a few :
https://pubmed.ncbi.nlm.nih.gov/2484541/
https://pubmed.ncbi.nlm.nih.gov/6541813/
https://pubmed.ncbi.nlm.nih.gov/2535320/
Wonder if it’s the same mechanism that zinc helped you — by making urine more alkaline ?
Chris... Does the degradation into 4-PY apply to excesses of NAD+ caused by direct NAD+ supplementation itself, or only by it's precursors?
I have tried to find this in the paper and your explanation but I must be missing it.
Yes it does.
Dr.Sinclair takes a ton & seems to be doing. Is that valid proof towards taking nmn.
Also I take Liposomal, which is kore effective & I guess I should limit that to 250 daily
At least Sinclair tells people he was 35 in the photo when people circulate photos of him and say he still looks 35 because of his supplement stack. 😂
I'm Generally suspect of Dr Sinclair.
What's the rational for making it liposomal? I have not encountered that yet! Interested!
Remember, we all have different DNA, and some can tolerate (or need) high doses, while that higher dose can cause severe problems for others. I'm glad that perspective is sprinkled into Masterjohn's review.
Yeah I'm also suspicious of the guy, he seems to be pretty great at Marketing and turning early research into products but we'll really only know in 50-80 years if all that stuff works as advertised.
Me too, dodgy geezer, dyes his hair but refutes it.loves himself too much. Glad Chris called this out
Agreed Sinclair is good but I wonder about his intentions & if he’s really for the science.
And this is lipo nmn I use. It’s suppose to be more effective per same dose. I think huberman introduced me to the brand. https://renuebyscience.com/product/lipo-nmn-powdered-liposomal-nmn2/
So in the end is it considered safe to continue using controlled release Niacin 500mg daily to help lower LDL-C and Lp(a) and increase HDL-C?
The controlled release is harder on the liver and I believe wasn't as effective at the lipid control. I'll try to add where I read that tomorrow.
Generally the flush version has been fantastic for my dad, good for my son, and though it helps me, has likely contributed to my pre-diabetes.
This^^
Loving the debate and references. 👍👍👍
Definitely contradicts.....
https://isom.ca/article/niacin-coronary-disease-longevity/
https://www.sciencedirect.com/science/article/pii/S0022227520352858
I'll let everyone else search the site for more
http://www.orthomolecular.org/resources/omns/v19n40.shtml
http://www.orthomolecular.org/resources/omns/v17n22.shtml
http://www.orthomolecular.org/resources/omns/v18n25.shtml
Some are questioning this single study: https://www.anhinternational.org/news/vit-b3-in-the-crosshairs-should-you-worry/?
or just re-iterating facts: http://orthomolecular.org/resources/omns/v20n04.shtml
Thank you Chris. the issue is not high glycine for me. I have low urine glycine., which contributes to salicylate and phenol intolerance. but when I was trying to take glycine-- I got a headache and nausea from it. and I do really well with low dose niacinamide. This is why I wondered if B3 would need to be adequate to handle the glycine.
You should be looking at glycine in plasma for this, not urine.
Yes ! thank you. I told my practitioner that I want amino acids tested in plasma instead .
Hmmm, this may change again in 2 years. Scientific discovery is a living ever-changing creature.
Did the blue zones take it?😉🙏
Well you don't have to live forever, just until you paid back your student loans. As far as NAD+ generation goes is there even a proven advantage of NMN over plain old niacinamide - considering the difference in price?