I had an interesting thought about the connection to migraines, but tell me if i am connecting the dots wrong here:
My gf saw a specialists for her migraines who said it is likely due to estrogen dominance which according to her can causes elevated histamine in the brain which causes/contributes to her migraines. Now i am not sure if this theory is correct but she took Calcium D Glucarate and it has been remarkably effective, more than anything else she has tried before.
Given the possible connection of Hydrogen Sulfide to estrogen as laid out here, and H2S's relationship to vasodilation which is also related to migraines, and that CoQ10 is needed to clear hydrogen sulfide as you mention in CoQ10 Deficiency Is Sulfur Toxicity, and how high doses of CoQ10 seem effective for migraines, could it be that for some types of migraines the culprit is perhaps Hydrogen Sulfide or it is H2S related or Sulfur toxicity in general?
Chris, could indole-3-carbinole or DIM, mainly found in cruciferous vegetables, which have a higher sulfate content, play the main role here? I-3-C and DIM lower estrogen and convert some of the bad estrogen into to better 2-hydroxy estrogen. However, they also slightly reduce testosterone.
Wondering if this is why many perimenopausal women are more likely to experience new onset of MCAS? My current understanding is that low estrogen means lowered ability to clear histamine…?
No, estrogen suppresses DAO in the gut. I’d have to research more on the changes in perimenopause but there is a lot of inflammatory signaling unique to the transition.
I've been in menopause for over a decade now but I'm wondering about why I ended up with normal estrogen levels but none of the other hormones (I was VERY sick) that needed replacement so I could recover from the endometriosis, fibroids, and bursting ovarian cysts that needed surgical removal.
I’m 36 & went into early perimenopause after giving birth at age 30. Within the last six years, I’ve developed MCAS, PCOS, Arthritis, Hypermobility, chronic SIBO, leaky gut, anxiety & OCD. Prior to all of this, I was healthy and living a normal life. I’m trying to put all the puzzle pieces together, as everything my body is struggling with seems to be connected to hormones. I’m estrogen dominant with fatigued adrenals & on biological progesterone - but nothing is helping my MCAS or SIBO, or my chronic pain for that matter. Looking for help, as my Drs and care team (my many Drs) can’t seem to get a handle on it.
I enjoy your curiosity, how you reason out and ask great questions! This as intriguing. I'm looking forward to more of your work.
It also struck me, that a medical nutritionist would be an asset in so many settings. I don't know if "medical nutritionist" is a thing, but it ought to be a thing. Your level of detail and research would make a difference, and sometimes the difference in a medical team setting.
Interesting that excess HS can cause both increased and decreased breast size. Curious why some women have tiny breasts and some have almost overly large. Anyone know how to optimally grow breast size for those who never really developed?
I wonder what would happen in developing females who have intense menstrual cramping and migraines, who have peri-menstrual nodular acne along the jawline (hormonal acne) and who have smaller breasts. Could molybdenum supplementation help the cramping, migraines, and peri-menstrual acne, and increase breast development? It is interesting, because vit B6 has been recommended in medical literature to reduce peri-menstrual worsening of acne (taken several days before and after the expected onset of menses every month).
NAC is a precursor to the amino acid cysteine, which in turn can be converted into H₂S (Hydrogen Sulfide) through specific enzymatic reactions.
However, the conversion of NAC to H₂S is part of a complex metabolic pathway and does NOT imply that taking NAC will directly and immediately produce high levels of H₂S. The body regulates these processes to maintain balance and homeostasis.
Just a thought, this being Pride Month: could this potentially be something of interest to the trans community especially those living in the "danger states"...
That should oppose estrogen and maybe reduce H2S endogenous production (I’m not sure about that) but I’m not saying H2S and E are identical, so I’m not sure if progesterone would oppose anything from H2S, except those things which are simply aggravations of direct roles of estrogen.
Perhaps the progesterone and anterior coated capsule getting pretty deep down in the gut could oppose the estrogen and this might reduce the H2s. Sounds like there’s nothing to lose with this experiment. I’ll go first.! 😏
the gut is just one source of H2S via some types of bacteria. Chris I believe is referring to endogenously produced H2S which is an essential gasotransmitter in the body. I'm curious to know how much gut-derived H2S might end up in the rest of the body though.
Okay, you already have estrogen onboard as a female. Add long-acting progesterone, and you can get tender breasts. Our body may adapt to the l/a progesterone and quiet down the tenderness after a while, depends on the dosing. Long-acting progesterone is quite helpful for sleep and sleep quality. It does add a bit more additional mass. Depending on the person's receptors it can be quite noticeable.
Hey Chris, smart stuff! Remember that in order for our bodies to convert sulfites into sulfates, the co-factors are molybdenum AND vitamin B2 (riboflavin-5-phosphate). Besides aromatase removing a methyl group off of testosterone that converts testosterone into estrogens (T-methy group=E2); sulfatases and beta-glucuronidases release toxic estrogens back into our systems by breaking apart already packaged liver phase 2 glucuronides and sulfation products of estrogen back into our systems to become reabsorbed. This is akin to raccoons ripping apart garbage bags when they are already in trash cans. And in doing so, these toxic estrogens become many times more toxic than when they first entered liver phase 1 and became processed by our cytochrome P450 pathways.
Dr. Dean Raffelock from Musings of a Medical Outlier on Substack
I had an interesting thought about the connection to migraines, but tell me if i am connecting the dots wrong here:
My gf saw a specialists for her migraines who said it is likely due to estrogen dominance which according to her can causes elevated histamine in the brain which causes/contributes to her migraines. Now i am not sure if this theory is correct but she took Calcium D Glucarate and it has been remarkably effective, more than anything else she has tried before.
Given the possible connection of Hydrogen Sulfide to estrogen as laid out here, and H2S's relationship to vasodilation which is also related to migraines, and that CoQ10 is needed to clear hydrogen sulfide as you mention in CoQ10 Deficiency Is Sulfur Toxicity, and how high doses of CoQ10 seem effective for migraines, could it be that for some types of migraines the culprit is perhaps Hydrogen Sulfide or it is H2S related or Sulfur toxicity in general?
Is the SUOX gene mutation something you ever look at in whole genome sequencing when people have high sulfite?
Chris, could indole-3-carbinole or DIM, mainly found in cruciferous vegetables, which have a higher sulfate content, play the main role here? I-3-C and DIM lower estrogen and convert some of the bad estrogen into to better 2-hydroxy estrogen. However, they also slightly reduce testosterone.
I don’t see how that constitutes “the main role.”
But what are the sources of hydrogen sulfide and how are we exposed to it?
Stay tuned
Anyone care to answer this? Do we get our daily recommended allowance of H2S from jet exhaust?
Thank you!
Maybe a small amount, we are more likely to get it from fracking. Sewerage plants etc.
From Jet fuel we get sulphur dioxide produced by burning the fuel. The short answer.
https://www.concawe.eu/wp-content/uploads/2017/01/rpt_13-8-2013-02451-01-e.pdf
https://t.me/climateviewerchat/10897
Wondering if this is why many perimenopausal women are more likely to experience new onset of MCAS? My current understanding is that low estrogen means lowered ability to clear histamine…?
No, estrogen suppresses DAO in the gut. I’d have to research more on the changes in perimenopause but there is a lot of inflammatory signaling unique to the transition.
I've been in menopause for over a decade now but I'm wondering about why I ended up with normal estrogen levels but none of the other hormones (I was VERY sick) that needed replacement so I could recover from the endometriosis, fibroids, and bursting ovarian cysts that needed surgical removal.
I believe it is normal to become “estrogen dominant” in menopause.
Huh? My estrogen went to ZERO with menopause.
I’m 36 & went into early perimenopause after giving birth at age 30. Within the last six years, I’ve developed MCAS, PCOS, Arthritis, Hypermobility, chronic SIBO, leaky gut, anxiety & OCD. Prior to all of this, I was healthy and living a normal life. I’m trying to put all the puzzle pieces together, as everything my body is struggling with seems to be connected to hormones. I’m estrogen dominant with fatigued adrenals & on biological progesterone - but nothing is helping my MCAS or SIBO, or my chronic pain for that matter. Looking for help, as my Drs and care team (my many Drs) can’t seem to get a handle on it.
Do you think there may be any connection between hydrogen sulfide/coq10 deficiency/sulfur toxicity and sulfa drug allergy/sensitivity?
Yes.
Do you know of any papers or resources to read more about the connection?
I have written a lot about sulfur and will continue to.
I enjoy your curiosity, how you reason out and ask great questions! This as intriguing. I'm looking forward to more of your work.
It also struck me, that a medical nutritionist would be an asset in so many settings. I don't know if "medical nutritionist" is a thing, but it ought to be a thing. Your level of detail and research would make a difference, and sometimes the difference in a medical team setting.
I’m not a nutritionist, but dietitians get trained in medical nutrition therapy and some specialize in it.
And how does this feed into MCAS aggravation by estrogen peaks?
Sulfite degranulates mast cells.
Interesting that excess HS can cause both increased and decreased breast size. Curious why some women have tiny breasts and some have almost overly large. Anyone know how to optimally grow breast size for those who never really developed?
I wonder what would happen in developing females who have intense menstrual cramping and migraines, who have peri-menstrual nodular acne along the jawline (hormonal acne) and who have smaller breasts. Could molybdenum supplementation help the cramping, migraines, and peri-menstrual acne, and increase breast development? It is interesting, because vit B6 has been recommended in medical literature to reduce peri-menstrual worsening of acne (taken several days before and after the expected onset of menses every month).
I find these connections fascinating.
I'd be wondering about the zinc status of the person as well
Wow. This is so interesting. Is it true that NAC turns into hydrogen sulfide? There seems to be some relationship with NAC and women's cycles.
NAC is a precursor to the amino acid cysteine, which in turn can be converted into H₂S (Hydrogen Sulfide) through specific enzymatic reactions.
However, the conversion of NAC to H₂S is part of a complex metabolic pathway and does NOT imply that taking NAC will directly and immediately produce high levels of H₂S. The body regulates these processes to maintain balance and homeostasis.
Just a thought, this being Pride Month: could this potentially be something of interest to the trans community especially those living in the "danger states"...
Possibly.
Wow!
So maybe getting some pure progesterone down into the gut via a capsule might be a solution?
That should oppose estrogen and maybe reduce H2S endogenous production (I’m not sure about that) but I’m not saying H2S and E are identical, so I’m not sure if progesterone would oppose anything from H2S, except those things which are simply aggravations of direct roles of estrogen.
Perhaps the progesterone and anterior coated capsule getting pretty deep down in the gut could oppose the estrogen and this might reduce the H2s. Sounds like there’s nothing to lose with this experiment. I’ll go first.! 😏
No, you are assuming H2S is coming from the gut. That is not at all what is happening.
🤔 so h2S SIBO isn’t coming from the gut….ok I’m looking forward to hearing this.
the gut is just one source of H2S via some types of bacteria. Chris I believe is referring to endogenously produced H2S which is an essential gasotransmitter in the body. I'm curious to know how much gut-derived H2S might end up in the rest of the body though.
“Interic coated capsule”
That was my first thought too.
Might make females' breasts tender and it can ummm (cough) increase their size a bit.
Really.
That would be estrogen. 😉
Okay, you already have estrogen onboard as a female. Add long-acting progesterone, and you can get tender breasts. Our body may adapt to the l/a progesterone and quiet down the tenderness after a while, depends on the dosing. Long-acting progesterone is quite helpful for sleep and sleep quality. It does add a bit more additional mass. Depending on the person's receptors it can be quite noticeable.
Nick Norwitz with a YT video out today indicating it LOWERS glp-1, unless I misunderstand.
Hey Chris, I pre-paid for a book you were writing. Did you ever publish it? You had stated that there were many delays. What's the status.
Hey Chris, smart stuff! Remember that in order for our bodies to convert sulfites into sulfates, the co-factors are molybdenum AND vitamin B2 (riboflavin-5-phosphate). Besides aromatase removing a methyl group off of testosterone that converts testosterone into estrogens (T-methy group=E2); sulfatases and beta-glucuronidases release toxic estrogens back into our systems by breaking apart already packaged liver phase 2 glucuronides and sulfation products of estrogen back into our systems to become reabsorbed. This is akin to raccoons ripping apart garbage bags when they are already in trash cans. And in doing so, these toxic estrogens become many times more toxic than when they first entered liver phase 1 and became processed by our cytochrome P450 pathways.
Dr. Dean Raffelock from Musings of a Medical Outlier on Substack