14 Comments
Sep 24Liked by Chris Masterjohn, PhD

Excellent and under appreciated.

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Sep 24Liked by Chris Masterjohn, PhD

My mother had anorexia, all her four kids have facial asymmetry to varying degrees left jaws didn’t develop properly. All suffer from undereating, two out of four has addiction problems alcohol then crash from benzos another cocaine problems. Anxiety depression, mother has nervous breakdown with delusionment issues.

Safe to say a this was quite an earth shattering read.

Thanks Chris

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Hi, Chris. Sulfite is a possible non IgE dependent trigger of mast cell degranulation https://eurekamag.com/research/048/889/048889782.php?srsltid=AfmBOooMsZd4vrk5eckAkW-C1a3IFIYBoakoTxPxrv8H1avGQoy2MHt1

Which May Play a role in asthma, artritis, anaphilaxis.

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author

I know.

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is it safe to assume that sulfur dysregulation can and will cause problems with oxalates in and outside of the body based on the fact that sulfite depletes b1, b6 and b9? these are coincidentally the b's that are potentially critical for oxalate metabolism.

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author

If you’re asking if they interact, yes that makes sense.

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"There are no and will never be any randomized controlled trials testing whether sulfite administration causes anxiety in humans." Why on earth not? This sounds extremely important!

I don't recall if I mentioned this book previously on this Substack, but Nutrient Power by Dr. William Walsh strikes me as foundationally important for understanding the connection between micronutrients and mental health. Dr. Walsh focuses especially on vitamin B6 and zinc (esp. zinc to copper ratio). Dr. Walsh treated and cured many cases of apparently incurable mental/behavioral disorders by focusing on diet and supplements.

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author

Well you have a point, I could see them doing it with levels that are commonly used in foods and medications, but I don’t think they would approve one at levels that were thought to be above those usually used and toxic to the brain.

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because it's not considered ethical. whereas in animal research, the scientific profession (and society in general) has less qualms about testing hypotheses on animals.

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Didn't you recently send an email out regarding Sulfur Metabolism and Mercury? I'm going through that now with BIG problems. I can't find the post or email. I have amalgam stuck in my lower jaw bone and infected cavitation from where my wisdom teeth were removed 25 years ago...no wonder I can't get better!

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author

I don’t recall saying anything about mercury. But see “protocols” in the menu.

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Thank you, Chris! I need to schedule another appt with you soon.

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How do I know if there is a disturbance in the function of the gene or something to pay attention to? For example, I have rs1081975 CG, but I don't know what it indicates in this case.

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author

We don't know more than what I wrote. In general, I think common polymorphisms are usually. much less important than rare mutations.

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