The Masterjohn Genetic Choline Calculator is a free tool you can use to turn your raw data file from Ancestry or 23andMe into a precise recommendation of how much choline you should aim to get from food! Click here to start using it: The Masterjohn Genetic Choline Calculator
I'm very excited to use the calculator, however, I have a whole-genome .vcf file that might not be the right format, but also is much larger than 25 MB (~1.5 GB). *Probably* it's unsustainable for you to maintain a site where you process such large files for free. Would you consider creating a calculator form where we can enter the alleles for the SNPs and it spits out a recommendation? That seems like it'd be the easiest way to support whole-genome files.
Hi Chris, here Ben Lynch says it doesn’t matter how much choline you eat unless you fix the enzyme behind the process https://youtube.com/shorts/1oGbl6OHty4?si=sTTWrDCs1RXQov8H what do you think? It seems contradictory to what you say
hey Chris, thanks so much for this info! I am confused about something, however. The NOW brand sunflower lecithin powder states that in a 10g serving (1 1/3 TBSP), it contains 2500mg of phosphatidylcholine. If we calculate 15% of that as actual choline, that nets around 375mg, or approximately 2.75 yolk equivalents? I see you state 1TBSP = 1 yolk equivalent, so I am not sure which would be correct here?
My requirement is 7 yolks, and I started taking 500mg TMG as half my requirement, so I am trying to figure out the other half. Thank you so much for everything you do!
Hi! I downloaded my raw data from TellmeGen and it didn't work. I tried unzipping the file, which gave me a csv file. Didn't work. Tried converting it to a text file, that didn't work either. Any help?
Quick question. How come when calculating food sources of choline, when looking at eggs for instance, majority of that is Phosphatidylcholine, but you then aren’t only taking 15% of that?
Compared with supplements like Phosphatidylcholine capsules you say to take only 15% as the amount of choline listed. Any reason why how a supplement listing 136mg of Phosphatidylcholine is not the same as the egg yolk equivalent that has 136mg where 93% of that is Phosphatidylcholine? Just confused why for the food sources 100% of Phosphatidylcholine goes towards the daily requirement, but with the PC supplement you say to calculate only 15%.
It just looks like according to your calculator, 136mg of PC capsules should be roughly equivalent to one egg yolk Since 93% of an egg yolk is listed as PC.
Because that’s the amount of choline in the food, not the amount of phosphatidylcholine, whereas in a supplement, they list the phosphatidylcholine mass.
Ok I think I understand now. So on the database for egg yolk, when dividing by 5 to get single yolk breakdown it says:
Phosphatidylcholine: 126
Total Choline 136.
That 126 contributes to daily needs, 100%. Because in reality egg yolk actually has 840mg of Phosphatidylcholine? Essentially calculating the 15% automatically?
So on the database when it says Phosphatidylcholine: 126, it’s saying that 126mg of actual choline is coming from Phosphatidylcholine?
Just making sure I understand this correctly. Other nutrients seem a little more straight forward. The potassium listed in food is elemental potassium. And even on supplements it lists elemental potassium even though when you look closer you can see that 98mg of potassium is coming from say 275mg of potassium citrate.
I think the issue with phosphatidylcholine is that you can’t fit that much in a capsule, so you have to market it as the whole phospholipid so that it looks like there is more of it.
Hey @ChrisMasterjohn would it be possible to send me the SNPs to watch for the genetic choline calculator in a PM. Alternatively, if you list them, I can send my alleles to you, you could calculate for me.
The reason is that I used Nebula, and the input files are not compatible.
Hi Chris,
I'm very excited to use the calculator, however, I have a whole-genome .vcf file that might not be the right format, but also is much larger than 25 MB (~1.5 GB). *Probably* it's unsustainable for you to maintain a site where you process such large files for free. Would you consider creating a calculator form where we can enter the alleles for the SNPs and it spits out a recommendation? That seems like it'd be the easiest way to support whole-genome files.
All the best,
Braden
I see the utility, but don't think I'll be doing that any time soon. Thanks for the recommendation though!
Chris this is a great idea and should be easy to implement
Hello,
I'm wondering if I can use a choline supplement to help reach the amount I need, and which form of choline would be best?
Hey Chris,
Is it compatible to use with Myheritage?
Hi Chris, here Ben Lynch says it doesn’t matter how much choline you eat unless you fix the enzyme behind the process https://youtube.com/shorts/1oGbl6OHty4?si=sTTWrDCs1RXQov8H what do you think? It seems contradictory to what you say
hey Chris, thanks so much for this info! I am confused about something, however. The NOW brand sunflower lecithin powder states that in a 10g serving (1 1/3 TBSP), it contains 2500mg of phosphatidylcholine. If we calculate 15% of that as actual choline, that nets around 375mg, or approximately 2.75 yolk equivalents? I see you state 1TBSP = 1 yolk equivalent, so I am not sure which would be correct here?
My requirement is 7 yolks, and I started taking 500mg TMG as half my requirement, so I am trying to figure out the other half. Thank you so much for everything you do!
https://www.iherb.com/pr/now-foods-sunflower-lecithin-pure-powder-1-lb-454-g/59514
I would go with the label calculation since it is specific to the product (hopefully).
Very interesting and helpful thanks. I'm curious whether a high "methylfolate score" also implies anything about your folate needs?
i converted the MyHeritage .csv file to tab-delimited .txt, but no luck so far.
"Error: The uploaded file is damaged or is not in a format that we recognize."
any idea how to fix this?
Hi! I downloaded my raw data from TellmeGen and it didn't work. I tried unzipping the file, which gave me a csv file. Didn't work. Tried converting it to a text file, that didn't work either. Any help?
Hi Chris,
I'd really like to use the Choline Calculator, but I'm wondering what the data privacy/security is like.
Hey Chris,
Quick question. How come when calculating food sources of choline, when looking at eggs for instance, majority of that is Phosphatidylcholine, but you then aren’t only taking 15% of that?
Compared with supplements like Phosphatidylcholine capsules you say to take only 15% as the amount of choline listed. Any reason why how a supplement listing 136mg of Phosphatidylcholine is not the same as the egg yolk equivalent that has 136mg where 93% of that is Phosphatidylcholine? Just confused why for the food sources 100% of Phosphatidylcholine goes towards the daily requirement, but with the PC supplement you say to calculate only 15%.
It just looks like according to your calculator, 136mg of PC capsules should be roughly equivalent to one egg yolk Since 93% of an egg yolk is listed as PC.
Thanks so much!
Because that’s the amount of choline in the food, not the amount of phosphatidylcholine, whereas in a supplement, they list the phosphatidylcholine mass.
Ok I think I understand now. So on the database for egg yolk, when dividing by 5 to get single yolk breakdown it says:
Phosphatidylcholine: 126
Total Choline 136.
That 126 contributes to daily needs, 100%. Because in reality egg yolk actually has 840mg of Phosphatidylcholine? Essentially calculating the 15% automatically?
So on the database when it says Phosphatidylcholine: 126, it’s saying that 126mg of actual choline is coming from Phosphatidylcholine?
Just making sure I understand this correctly. Other nutrients seem a little more straight forward. The potassium listed in food is elemental potassium. And even on supplements it lists elemental potassium even though when you look closer you can see that 98mg of potassium is coming from say 275mg of potassium citrate.
Yes you have it right.
I think the issue with phosphatidylcholine is that you can’t fit that much in a capsule, so you have to market it as the whole phospholipid so that it looks like there is more of it.
Hey @ChrisMasterjohn would it be possible to send me the SNPs to watch for the genetic choline calculator in a PM. Alternatively, if you list them, I can send my alleles to you, you could calculate for me.
The reason is that I used Nebula, and the input files are not compatible.
Please re-ask this over at the Masterpass forum and I’ll paste the calculation in the comments.