I'm 76 and have almost no grey hair. Several university studies suggested that catalase enzyme prevents hydrogen peroxide from bleaching the hair at the follicles. The more glutathione being available keeps catalase levels high. If this is all true, perhaps my love of glutathione producing foods like collard greens may hold the key for my lack of grey. I've always been a supplement taker, so NAC supplementation may be an advantage for more glutathione and less grey hair. Have you seen the study on why hair turns grey by the university (I can't remember where, but it can be googled)? I read this years ago.
A high concentration of H2O2 accumulates in graying hair follicles, as described in published reports [5], [6], which might be explained in part by the intrinsic deficiency of catalase in gray hair since catalase is an important antioxidant enzyme that catalyzes the conversion of H2O2 to water and molecular oxygen [6].
I bet I'm homozygous for this, I found my first grey hair at age 10 and after qualifying as a junior doctor aged 23 ( which was very stressful ) I had such a lot of grey that I started dying it and have done ever since. I have exceptionally pale skin, freckles from the sun and green eyes, although my natural hair colour was dark brown. Interestingly I also had low copper ( and zinc) when they were measured 6 years ago, aged 49, and a Dutch test showed I am along the lower limit of cortisol with a normal 24hr pattern.
I have the GG genotype (R402R), hence I’m homozygous for arginine. So I take it that I can no longer blame genetics for my hair sprouting grey hairs at 17 and I really need to double down on managing stress levels!
So Chris, would taking the supplement peptide KPV, which is supposed to be a mimic for MSH, change any of the issues you discussed above? KPV is becoming popular so it would be good to know better how it relates to other substances in the body.
This question is not about graying hair but I wasn't sure where else to ask it. 😆
Can you think of a specific inborn error of metabolism that would correspond to a migraine lasting 3 years (onset at 16) coupled with rhabdomyolysis that presents with moderate exercise? This is for a client of mine who has exhausted mainstream options, visited top neurologists, tried all the newest and most expensive drugs, (Nertec, etc) and is out of mainstream options.
His pain level is often 9 out of 10. I'm recommending genetic testing, organic acid tests, and everything from your post "A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn’t, Analyze." But while we wait for results, I'd love to get going on something. I'm starting him on 400 mg of riboflavin today. Would you throw everything at it for now until we get results: COQ10, riboflavin, biotin, thiamine, niacin, B6, or should I do it in groups, try the red pattern and see what that comes up with?
Another piece of info, he was helped somewhat by the keto diet when done strictly and able to reach a 1.5 mmol/dL blood level as measured through the Keto Mojo. Also has gut problems that I will address. I'm thinking he should try exogenous ketone salts. Any other thoughts would be greatly appreciated. This definitely feels beyond my expertise but I know you have a long waiting list. Do you ever move people up for emergencies? If not, I'll work with them as best as I am able.
Migraine could be caused by virtually any of hundreds, but especially anything impacting sulfur metabolism.
Rhabdo -- any impacting myopathy.
I'd get him in BioOpt.
In general throwing everything at something is warranted when desperation level is high and expected information level is low.
If someone responds well to something I think it makes sense to try leaning into it further or accentuating it in a controlled manner. For example, keto benefit implies possible benefits of carb restriction, protein restriction, lower blood glucose, or higher blood ketones. Exogenous ketones would replicate part of that.
I think the sauna effect is very short-lived compared to the cumulative effect of ambient temperature, and I think not exercising is a terrible option for anyone pursuing health. So I would focus on cumulative ambient temperature.
Would you say gingers have excess copper or a deficiency in copper? this makes me think an excess..as gingers don't usually grey and have lots of freckles..
I'm 76 and have almost no grey hair. Several university studies suggested that catalase enzyme prevents hydrogen peroxide from bleaching the hair at the follicles. The more glutathione being available keeps catalase levels high. If this is all true, perhaps my love of glutathione producing foods like collard greens may hold the key for my lack of grey. I've always been a supplement taker, so NAC supplementation may be an advantage for more glutathione and less grey hair. Have you seen the study on why hair turns grey by the university (I can't remember where, but it can be googled)? I read this years ago.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3973559/
Excerpt:
A high concentration of H2O2 accumulates in graying hair follicles, as described in published reports [5], [6], which might be explained in part by the intrinsic deficiency of catalase in gray hair since catalase is an important antioxidant enzyme that catalyzes the conversion of H2O2 to water and molecular oxygen [6].
apparently I'm heterozygous for these Genotype if I read my selfdecode correct. Also european
I bet I'm homozygous for this, I found my first grey hair at age 10 and after qualifying as a junior doctor aged 23 ( which was very stressful ) I had such a lot of grey that I started dying it and have done ever since. I have exceptionally pale skin, freckles from the sun and green eyes, although my natural hair colour was dark brown. Interestingly I also had low copper ( and zinc) when they were measured 6 years ago, aged 49, and a Dutch test showed I am along the lower limit of cortisol with a normal 24hr pattern.
Love this post! I’ll be checking my alleles! Thanks!
I have the GG genotype (R402R), hence I’m homozygous for arginine. So I take it that I can no longer blame genetics for my hair sprouting grey hairs at 17 and I really need to double down on managing stress levels!
I’m just a lay person so much of this is way above me but was interested to know if any of these interactions impacted on vitiligo
All melanin is the same, hair, eyes, and skin. It impacts all of it.
Technically there are several types of melanin that are derivatives but they are all equally dependent on the info here.
So Chris, would taking the supplement peptide KPV, which is supposed to be a mimic for MSH, change any of the issues you discussed above? KPV is becoming popular so it would be good to know better how it relates to other substances in the body.
I don't know much about it but quick searching suggests it doesn't impact skin pigmentation.
So get tested first? Does a copper supplement help?
It could if you are copper deficient.
I think I’ll just make sure I eat more dark chocolate to cover my basis. I am concerned that my zinc intake would lower my copper too much.
This question is not about graying hair but I wasn't sure where else to ask it. 😆
Can you think of a specific inborn error of metabolism that would correspond to a migraine lasting 3 years (onset at 16) coupled with rhabdomyolysis that presents with moderate exercise? This is for a client of mine who has exhausted mainstream options, visited top neurologists, tried all the newest and most expensive drugs, (Nertec, etc) and is out of mainstream options.
His pain level is often 9 out of 10. I'm recommending genetic testing, organic acid tests, and everything from your post "A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn’t, Analyze." But while we wait for results, I'd love to get going on something. I'm starting him on 400 mg of riboflavin today. Would you throw everything at it for now until we get results: COQ10, riboflavin, biotin, thiamine, niacin, B6, or should I do it in groups, try the red pattern and see what that comes up with?
Another piece of info, he was helped somewhat by the keto diet when done strictly and able to reach a 1.5 mmol/dL blood level as measured through the Keto Mojo. Also has gut problems that I will address. I'm thinking he should try exogenous ketone salts. Any other thoughts would be greatly appreciated. This definitely feels beyond my expertise but I know you have a long waiting list. Do you ever move people up for emergencies? If not, I'll work with them as best as I am able.
Migraine could be caused by virtually any of hundreds, but especially anything impacting sulfur metabolism.
Rhabdo -- any impacting myopathy.
I'd get him in BioOpt.
In general throwing everything at something is warranted when desperation level is high and expected information level is low.
If someone responds well to something I think it makes sense to try leaning into it further or accentuating it in a controlled manner. For example, keto benefit implies possible benefits of carb restriction, protein restriction, lower blood glucose, or higher blood ketones. Exogenous ketones would replicate part of that.
If hetero or homozygous for rs1126809, would you recommend avoiding regular sauna sessions or extended cardio which raises body temperature?
I think the sauna effect is very short-lived compared to the cumulative effect of ambient temperature, and I think not exercising is a terrible option for anyone pursuing health. So I would focus on cumulative ambient temperature.
I unsubscribed by accident, please return to my previous status. Best
Would you say gingers have excess copper or a deficiency in copper? this makes me think an excess..as gingers don't usually grey and have lots of freckles..
I wouldn't say anything about their copper unless they measured it.