I had the same low globulins (2) and high A/G ratio (2.4) as you and supplemented with 10 mg per day of biotin for a month. Follow up testing showed my globulin levels unchanged.
I then tested my copper levels which are low-normal at 72. Is it possible low copper is the cause of low globulins?
I had the same low globulins (2) and high A/G ratio (2.4) as you and supplemented with 10 mg per day of biotin for a month. Follow up testing showed my globulin levels unchanged.
I then tested my copper levels which are low-normal at 72. Is it possible low copper is the cause of low globulins?
Maybe low copper increases oxidative stress in the kidney which damages tubules causing globulins to get lost in the urine? Albumin levels have remained consistent, which I suppose contradicts this hypothesis.
Sure, that might be possible. I would never have supplemented biotin on the basis of the A/G, which I found to be among the least interesting side notes within my data.
Yeah, I actually started taking the biotin due to oxalate issues but developed the globulin deficiency before starting biotin. I was curious to see if the biotin would fix it. Thought I'd note that it did not.
When I went to get tested to see if my globulins had normalized the woman at the front desk sneezed and by 5pm I had a sore throat. So I was able to confirm that I was immune deficient even before receiving the results of my bloodwork. Sure enough the globulins were still low. A few days later I got my copper results back suggesting I'm deficient.
I started supplementing 4mg/day of copper in addition to 1 ounce of liver. I will report my results back here in two months, in case it might be helpful to anyone reading this.
According to cronometer my daily intake of copper was 5 mg/day from food. Pretty sure I developed the copper deficiency because I was eating my liver in the same meal as my oatmeal.
So I ended up in the emergency room on the 13th due to a nose bleed that wouldn't stop. The low copper led me to suspect low platelets. The hospital ran a CBC and everything came back normal.
Now I suspect a deficiency in the fat soluble vitamins caused by a low fat diet. My cholesterol levels have dipped from 190 to 130 so there may be some issues with bile and fat absorption in addition to the low fat diet.
A deficiency in Vitamin K would help explain why I wasn't able to clot enough to stop the bleeding. Another possibility is problems forming collagen due to low copper.
A follow up visit with my doctor the next day revealed the protein in my blood had risen from 6.6 to 7.4, albumin from 4.6 to 4.8, and globulins form 2 to 2.6.
The morning of the blood test I supplemented with 25,000 IU of vitamin A and 900 mcg of Vitamin K2 with a high fat meal. The blood test was 8 days after I began supplementing 4mg/day of copper.
So either 4mg/day of copper was enough to correct a marginal deficiency in 8 days or a high dose of vitamin A about 5 hours before a comprehensive metabolic profile was enough to correct the globulin deficiency.
Did you get total and ionized serum calcium? Calcium is the activating factor for platelet aggregation.
The movements in proteins are very small. I would be careful of over-interpreting them, especially if you only have one previous lab measurement for them.
Serum calcium from the CBC is 9.8, which is consistent with past results that fluctuate between 9 and 10. No ionized serum calcium.
I've had four CMP's run this year.
1/5/23: protein 7.1, albumin 4.7, globulins 2.4. This is typical for me.
2/28/23: protein 6.7, albumin 4.7, globulins 2.
4/3/23: protein 6.6, albumin 4.6, globulins 2.
4/14/23: protein 7.4, albumin 4.8, globulins 2.6.
The first three were taken in the morning after an overnight fast of 12 hours. The last one was taken in the afternoon 2-3 hours after breakfast, so that may be artificially increasing the values?
I'll get another CMP run when I retest my copper levels in a few weeks.
As of right now the nose bleed has been fixed with a few days with nasal packing they put in at the hospital.
Alkalinity can drive the calcium into albumin, which can lower the ionized fraction.
Yes I think eating is a huge confounder and you should always measure labs you are comparing in the same state.
Fasting makes things easier because so many labs do require fasting, and because most literature values are from the mornings after an overnight fast.
When I see these values it looks to me like you were in the 2.4-2.6 range and temporarily dipped to the 2.0 range, or perhaps that you are always in the 2.0-2.4 range during an overnight fast and nothing changed.
I had the same low globulins (2) and high A/G ratio (2.4) as you and supplemented with 10 mg per day of biotin for a month. Follow up testing showed my globulin levels unchanged.
I then tested my copper levels which are low-normal at 72. Is it possible low copper is the cause of low globulins?
Maybe low copper increases oxidative stress in the kidney which damages tubules causing globulins to get lost in the urine? Albumin levels have remained consistent, which I suppose contradicts this hypothesis.
Do you have any insight on this?
Sure, that might be possible. I would never have supplemented biotin on the basis of the A/G, which I found to be among the least interesting side notes within my data.
Yeah, I actually started taking the biotin due to oxalate issues but developed the globulin deficiency before starting biotin. I was curious to see if the biotin would fix it. Thought I'd note that it did not.
When I went to get tested to see if my globulins had normalized the woman at the front desk sneezed and by 5pm I had a sore throat. So I was able to confirm that I was immune deficient even before receiving the results of my bloodwork. Sure enough the globulins were still low. A few days later I got my copper results back suggesting I'm deficient.
I started supplementing 4mg/day of copper in addition to 1 ounce of liver. I will report my results back here in two months, in case it might be helpful to anyone reading this.
According to cronometer my daily intake of copper was 5 mg/day from food. Pretty sure I developed the copper deficiency because I was eating my liver in the same meal as my oatmeal.
That’s possible, with the oatmeal. I look forward to seeing your results!
So I ended up in the emergency room on the 13th due to a nose bleed that wouldn't stop. The low copper led me to suspect low platelets. The hospital ran a CBC and everything came back normal.
Now I suspect a deficiency in the fat soluble vitamins caused by a low fat diet. My cholesterol levels have dipped from 190 to 130 so there may be some issues with bile and fat absorption in addition to the low fat diet.
A deficiency in Vitamin K would help explain why I wasn't able to clot enough to stop the bleeding. Another possibility is problems forming collagen due to low copper.
A follow up visit with my doctor the next day revealed the protein in my blood had risen from 6.6 to 7.4, albumin from 4.6 to 4.8, and globulins form 2 to 2.6.
The morning of the blood test I supplemented with 25,000 IU of vitamin A and 900 mcg of Vitamin K2 with a high fat meal. The blood test was 8 days after I began supplementing 4mg/day of copper.
So either 4mg/day of copper was enough to correct a marginal deficiency in 8 days or a high dose of vitamin A about 5 hours before a comprehensive metabolic profile was enough to correct the globulin deficiency.
Did you get total and ionized serum calcium? Calcium is the activating factor for platelet aggregation.
The movements in proteins are very small. I would be careful of over-interpreting them, especially if you only have one previous lab measurement for them.
Serum calcium from the CBC is 9.8, which is consistent with past results that fluctuate between 9 and 10. No ionized serum calcium.
I've had four CMP's run this year.
1/5/23: protein 7.1, albumin 4.7, globulins 2.4. This is typical for me.
2/28/23: protein 6.7, albumin 4.7, globulins 2.
4/3/23: protein 6.6, albumin 4.6, globulins 2.
4/14/23: protein 7.4, albumin 4.8, globulins 2.6.
The first three were taken in the morning after an overnight fast of 12 hours. The last one was taken in the afternoon 2-3 hours after breakfast, so that may be artificially increasing the values?
I'll get another CMP run when I retest my copper levels in a few weeks.
As of right now the nose bleed has been fixed with a few days with nasal packing they put in at the hospital.
Alkalinity can drive the calcium into albumin, which can lower the ionized fraction.
Yes I think eating is a huge confounder and you should always measure labs you are comparing in the same state.
Fasting makes things easier because so many labs do require fasting, and because most literature values are from the mornings after an overnight fast.
When I see these values it looks to me like you were in the 2.4-2.6 range and temporarily dipped to the 2.0 range, or perhaps that you are always in the 2.0-2.4 range during an overnight fast and nothing changed.