Thank you Chris for the balanced article clarifying this study. Are you currently experimenting with any of these supplements NAD+ related supplements, Niacain/Niacinamide/Nicotinamide riboside/etc?
I wish the corrupted FDA considered mouse studies the way you put it in this article, instead of the way they say it.
"The study doesn’t show anything about what happens to human taking NR at any dose.
However, the study does raise a safety concern that as little as 23-29 milligrams of NR per day could fuel cancer growth and metastasis in specific patient populations to whom we believe this mouse model might be generalized."
FYI - Eighteen months after successful treatment of Lymphoma (axilla) I tried NMN on the recommendation of a Harvard medical researcher active online. Within a week of starting NMN what I thought was a cyst had formed in my lower left jaw. The "cyst" was 2 centimetres in diameter after 10 days, and I stopped taking the NMN as it seemed too much of a coincidence. A year later the "cyst" had not grown further, and I had it surgically removed. The "cyst" was routinely biopsied and declared to be lymphoma. Subsequent PET-CT scans were negative. Just putting this out there...
Your calculation for HED for the 400mg/kg of NR given to the mice is this study seems incorrect. For some reason you divided by 1230 instead of by 12.3 - which would give you 32.5mg/kg for a person or about a dose of 2276mg for a 70 kg person. Big difference don’t you think.
Really appreciate the analysis. What is the normal conversion from NR to NAD in mice cells? If there's a differencem maybe that ratio ought to apply when extrapolating dosage from mice to human.
Also it seems strange to just pick on NR supplementation as it can be generalized to any nutrient essential for cell function or growth, like you mentioned with protein. I wonder if this is why I've read many cases that a 21 day water fast works as an immediate an effective cancer intervention.
I ordered the Vitamins and Minerals cheat sheet and have never received a link. I have sent two follow-up emails requesting the information that I purchased. Crickets.
I would like to buy additional material but am put off by the lack of response. Is anyone else experiencing something similar???
They need to vilify the NAD+ supplements so they can be taken off the market before China releases one of the viral hemorrhagic fever viruses. They kill by depleting NAD+.
Thank you Chris for the balanced article clarifying this study. Are you currently experimenting with any of these supplements NAD+ related supplements, Niacain/Niacinamide/Nicotinamide riboside/etc?
I wish the corrupted FDA considered mouse studies the way you put it in this article, instead of the way they say it.
"The study doesn’t show anything about what happens to human taking NR at any dose.
However, the study does raise a safety concern that as little as 23-29 milligrams of NR per day could fuel cancer growth and metastasis in specific patient populations to whom we believe this mouse model might be generalized."
Now, that's science! Not TheScience™
FYI - Eighteen months after successful treatment of Lymphoma (axilla) I tried NMN on the recommendation of a Harvard medical researcher active online. Within a week of starting NMN what I thought was a cyst had formed in my lower left jaw. The "cyst" was 2 centimetres in diameter after 10 days, and I stopped taking the NMN as it seemed too much of a coincidence. A year later the "cyst" had not grown further, and I had it surgically removed. The "cyst" was routinely biopsied and declared to be lymphoma. Subsequent PET-CT scans were negative. Just putting this out there...
Your calculation for HED for the 400mg/kg of NR given to the mice is this study seems incorrect. For some reason you divided by 1230 instead of by 12.3 - which would give you 32.5mg/kg for a person or about a dose of 2276mg for a 70 kg person. Big difference don’t you think.
Really appreciate the analysis. What is the normal conversion from NR to NAD in mice cells? If there's a differencem maybe that ratio ought to apply when extrapolating dosage from mice to human.
Also it seems strange to just pick on NR supplementation as it can be generalized to any nutrient essential for cell function or growth, like you mentioned with protein. I wonder if this is why I've read many cases that a 21 day water fast works as an immediate an effective cancer intervention.
I ordered the Vitamins and Minerals cheat sheet and have never received a link. I have sent two follow-up emails requesting the information that I purchased. Crickets.
I would like to buy additional material but am put off by the lack of response. Is anyone else experiencing something similar???
They need to vilify the NAD+ supplements so they can be taken off the market before China releases one of the viral hemorrhagic fever viruses. They kill by depleting NAD+.