The new paper showing the spike protein is found in armpit lymph nodes at least 60 days after vaccination also shows that immune imprinting from vaccination leads to "original antigenic sin."
Mar 1, 2022·edited Mar 1, 2022Liked by Chris Masterjohn, PhD
Dear Chris, thanks for the great breakdown. I hope you are later able to comment on the new reverse transcription study you were touching on here: https://twitter.com/ChrisMasterjohn/status/1497556655466287106 Igor Chudov did a recent post checking a sequence from that article in BLAST (https://igorchudov.substack.com/p/dna-transcribed-from-pfizer-mrna). The results were nightmarish, to say the least. Really hope we can see your super clear breakdowns on this frightening reverse transcription issue. Keep up the good work!
Your arguments are specious and do not validate the presence of OAS. Your graph does not document OAS. Read: The “original antigenic sin ”and its relevance for SARS-CoV-2 (COVID-19) vaccination, Ger T. Rijkers a , b , ∗ , Frans J. van Overveld a Clinical Immunology Communications 1 (2021) 13–16
Every single study of covid ends with a recommendation for mRNA transfection, regardless of whether the data suggests that. Seems fishy. Anyway, I'll pass on one of these "vaccinations". I took my chances with covid without one of those. Got it, recovered and I'll continue to take my chances without one going forward.
After having just complemented your genome integration analysis, I was afraid I would have to issue a negative review on this one. I'll just say I second Robert Hansen, below. The paper demonstrates that infection resulted in measurable sensitization against Alpha and Delta, leading to a more balanced response. That's not OAS. OAS is not real.
As for as the observed broader baseline cross-affinity, it could be the case that the modRNA is causing a lot more variation in spike expression (as in "mutant" spikes) and/or APC epitope selection vs infection. There may also be more germ centers simultaneously engaged, resulting in less consensus. As for affinity maturation you wouldn't think that would lead to more cross-affinity since it's all measured as vs Wuhan, and I would say it's more likely that long-duration exposure leads to higher dominance of the high affinity clones. And yet that doesn't seem to be happening. So I provisionally lean toward the mutant spike explanation.
COVID Vaccines Impair Response to Variants of Concern
This paper in Cell reads like the authors are paid cheerleaders for the vaccine without stopping to ponder the significant drawbacks. Madness.
Horrible!!!
Dear Chris, thanks for the great breakdown. I hope you are later able to comment on the new reverse transcription study you were touching on here: https://twitter.com/ChrisMasterjohn/status/1497556655466287106 Igor Chudov did a recent post checking a sequence from that article in BLAST (https://igorchudov.substack.com/p/dna-transcribed-from-pfizer-mrna). The results were nightmarish, to say the least. Really hope we can see your super clear breakdowns on this frightening reverse transcription issue. Keep up the good work!
Your arguments are specious and do not validate the presence of OAS. Your graph does not document OAS. Read: The “original antigenic sin ”and its relevance for SARS-CoV-2 (COVID-19) vaccination, Ger T. Rijkers a , b , ∗ , Frans J. van Overveld a Clinical Immunology Communications 1 (2021) 13–16
Every single study of covid ends with a recommendation for mRNA transfection, regardless of whether the data suggests that. Seems fishy. Anyway, I'll pass on one of these "vaccinations". I took my chances with covid without one of those. Got it, recovered and I'll continue to take my chances without one going forward.
After having just complemented your genome integration analysis, I was afraid I would have to issue a negative review on this one. I'll just say I second Robert Hansen, below. The paper demonstrates that infection resulted in measurable sensitization against Alpha and Delta, leading to a more balanced response. That's not OAS. OAS is not real.
As for as the observed broader baseline cross-affinity, it could be the case that the modRNA is causing a lot more variation in spike expression (as in "mutant" spikes) and/or APC epitope selection vs infection. There may also be more germ centers simultaneously engaged, resulting in less consensus. As for affinity maturation you wouldn't think that would lead to more cross-affinity since it's all measured as vs Wuhan, and I would say it's more likely that long-duration exposure leads to higher dominance of the high affinity clones. And yet that doesn't seem to be happening. So I provisionally lean toward the mutant spike explanation.