Balancing Vitamin C and Glutathione: Preliminary Report

Beyond a certain dose, vitamin C can begin taxing glutathione and rendering excess nitric oxide toxic. Here's how to prevent that.

I am not a medical doctor and this is not medical advice. Please see the full disclaimer at the bottom.

This Content is Superseded by the Final Report

Please note that this article is maintained for historical purposes but the content and conclusions are fully superseded by the final report, which is now available:

Continue Reading the Preliminary Report

While I was writing my last post, Protecting Against Spike Protein Toxicity With Sulfur, Selenium, and Sunlight, I came across this paper from 2002 showing that, in dopamine-responsive brain cells, vitamin C worsens nitric oxide toxicity, while glutathione and N-acetyl-cysteine protect against it.

The context of this study was an investigation into the damage of dopamine-responsive brain cells in the context of Parkinson’s.

However, I believe this paper demonstrates a much more broadly applicable general principle: high doses of vitamin C need to be properly balanced with glutathione support in any context where nitric oxide toxicity might be important. That includes COVID and vaccine-induced spike protein toxicity, and it should be broadly applicable to inflammation in general.

I am working on a much more extensive report tying this together with vitamin C research in the context of COVID, general immunity, and cancer. I will likely release this report at the end of next week.

For now, I wanted to leave you with my preliminary take-home points so that you can take them under consideration now if you use high-dose vitamin C for any purpose.