Balancing Vitamin C and Glutathione: Final Report

Maintaining good GSH status is always important to protect high-dose C from generating oxalate and may often be important for preventing it from acting as a pro-oxidant. Cancer is an exception.

I am not a medical doctor and this is not medical advice. Please see the full disclaimer at the bottom.

In my preliminary report, I voiced the concern that high-dose vitamin C could deplete glutathione and worsen nitric oxide toxicity when not properly balanced with glutathione-boosting strategies. I suggested this applied to COVID, COVID vaccines, and to inflammation generally.

Having dived much deeper into the research, I retract the suggestion that the vitamin C is depleting glutathione in these contexts, but leave open the suggestion that it could. I broaden the scope of the need to balance these two stars of the antioxidant system, however, to include virtually all contexts. Except where high-dose vitamin C is used to assist chemotherapy in cancer treatment — where it is supposed to act as a pro-oxidant — maintaining good “glutathione hygiene” as well as maintaining your “suite of vitamin C-recycling nutrients” will likely always be necessary to prevent high-dose vitamin C from acting as a pro-oxidant and generating oxalate.