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237: Can a high-protein diet hurt nitric oxide and raise blood pressure?

Masterjohn Q&A Files Episode 237


Question: Can a high-protein diet hurt nitric oxide and raise blood pressure?

The people with OTC gene do have higher blood pressure because of lower nitric oxide. And they have a problem eating too much protein, but the protein is a problem, because they can exceed the capacity of the urea cycle and generate more ammonia. Whereas the OTC gene being low is what's driving the low nitric oxide to lower arginine production. So you are seeing the combination of this person should not eat too much protein. This person has low nitric oxide, high blood pressure, but I don't think it's the protein that's causing that. I think it's just low arginine synthesis due to low citrulline synthesis. And so they should supplement citrulline to improve their blood pressure. And they probably shouldn't eat too much protein, but I don't think that too much protein is going to be the thing that drives the high blood pressure.

This Q&A can also be found as part of a much longer episode, here:

083: Ask Me Anything About Nutrition, June 10, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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The Masterjohn Q&A Files
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Chris Masterjohn, PhD