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212: Could methylglyoxal be causing elevated fasting glucose in low-carbers?

Masterjohn Q&A Files Episode 212


Question: Could methylglyoxal be causing elevated fasting glucose in low-carbers?

Yes. I did my doctoral dissertation on methylglyoxal so I've covered it in a lot of different contexts, and the basic story is we know that diabetics have high methylglyoxal levels. We know that diabetics have high methylglyoxal-derived advanced glycation endproducts. And we know that this is true even when they're treated. Now that raises the question, does diabetes cause methylglyoxal to increase, or does methylglyoxal cause diabetes? And the answer is both. 

This Q&A can also be found as part of a much longer episode, here:

082: Ask Me Anything About Nutrition, February 7, 2021

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at You can sign up for a consultation at

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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The Masterjohn Q&A Files
We use Zoom, a video chatting software, in webinar mode. You can ask your question anonymously in text, but you can also ask it publicly, and you can even get "on stage" and share your mic, web cam, or screen with everyone.
Chris Masterjohn, PhD