Paid episode

The full episode is only available to paid subscribers of Harnessing the Power of Nutrients

196: Why would methylated vitamins increase pain sensitization?

Masterjohn Q&A Files Episode 196


Question: Why would methylated vitamins increase pain sensitization?

I'm not sure. Just to throw out some random threads that may or may not be of use. I think methylation in some people is going to lead to increased synthesis of dopamine. But in general, the effect is going to be to decrease the tonic pool of dopamine. There's going to be some degree to which it decreases other neuro-transmitters. And it's possible that if, particularly, if glycine is not stabilized, that you're going to lose the inhibitory effect of glycine and that you might also lose the effect of ambient glycine in coactivating NMDA receptors. Now off the top of my head, I would think that you would want the glycine there to support.

This Q&A can also be found as part of a much longer episode, here:

081: Ask Me Anything About Nutrition, December 9, 2020

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at You can sign up for a consultation at

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Listen to the Audio

I highly recommend watching the video above but you can also listen to the audio here:

Read the Transcript or Leave a Comment

Masterpass members have access to the transcript below.

Masterpass members can also read and leave comments below. Non-members can read and leave comments on the general podcast page.

Learn more about the Masterpass here.

The Masterjohn Q&A Files
We use Zoom, a video chatting software, in webinar mode. You can ask your question anonymously in text, but you can also ask it publicly, and you can even get "on stage" and share your mic, web cam, or screen with everyone.
Chris Masterjohn, PhD