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193: Why zinc deficiency causes resistance to thyroid and sex hormones and vitamins A and D

Masterjohn Q&A Files Episode 193


Question: Why zinc deficiency causes resistance to thyroid and sex hormones and vitamins A and D

The answer to that is because the, because all of those things carry out their gene expression function by binding to nuclear receptors. And all of the nuclear receptors to DNA using zinc finger motifs. Zinc finger motif means that in the nuclear receptor, there's a zinc ion that coordinates the primary structure of the protein, which is a long string of amino acids into a finger shape.

This Q&A can also be found as part of a much longer episode, here:

081: Ask Me Anything About Nutrition, December 9, 2020

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at You can sign up for a consultation at

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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The Masterjohn Q&A Files
We use Zoom, a video chatting software, in webinar mode. You can ask your question anonymously in text, but you can also ask it publicly, and you can even get "on stage" and share your mic, web cam, or screen with everyone.
Chris Masterjohn, PhD