Introduction
Question: MTHFR, Depression, Irritability, and Anxiety
So, if someone has an MTHFR snip, they don't have enough methylfolate. And so if they're treating it with methylfolate, the methylfolate causes the depression, irritability, and anxiety, then that's one thing. Whereas, if they have the MTHFR snip, they're not doing anything about it and they have depression, irritability, anxiety, that's another thing. So, if they're not doing anything about it and they have those problems, then it's probably from under-methylation. If they're supplementing methylfolate and that's causing the depression, irritability and anxiety, then my guess is that that is a temporary transient over-methylation state. That is a result of the body being adapted to a low methylfolate state and suddenly switching to a high methylfolate state. And I think the key to getting through that is to take small doses of the methylfolate and equilibrate to the lowest dose.
This is my "Start Here for Methylation" page I mentioned:
https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation
This Q&A can also be found as part of a much longer episode, here:
080: Ask Me Anything About Nutrition, December 2, 2020
DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.
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