169: Do Ketogenic Diets Lower Glutathione?

Masterjohn Q&A Files Episode 169

Introduction

Question: Do Ketogenic Diets Lower Glutathione?

And so what a ketogenic diet does is put you in a low insulin to glucagon ratio longterm and the insulin to glucagon ratio is what is used for the body to perceive whether it has enough energy to invest in making glutathione. And so the reason the liver's glutathione is going to go down on a ketogenic diet is because you're in the fasting state.

Glutathione synthesis is a fed state process. It's something that goes down in the fasting state and up in the fed state period. And so if you're using a diet that is mimicking the fasting state and is allowing you to carry out fasting state physiology for a longer period of time than you would be able to go on zero calories, then you're going to mimic the fasting state. And the fasting state is characterized by lower glutathione synthesis. And that's the end of it.

These are the studies we discussed on the ketogenic diet and glutathione levels:

https://pubmed.ncbi.nlm.nih.gov/18466343/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102314/

This Q&A can also be found as part of a much longer episode, here:

080: Ask Me Anything About Nutrition, December 2, 2020

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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