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152: Are the concerns about cyanocobalamin exaggerated?

Masterjohn Q&A Files Episode 152


Question: Are the concerns about cyanocobalamin exaggerated?

I'm not sure what people have said about the dangers. I know that I have been a critic of cyanocobalamin relative to other forms of B12 and then, other people may have used something I said maybe in an exaggerated way. And then there might be just much marketing that I haven't actually been exposed to where people have come up with their own marketing claims around other forms of B12.

So my opinion is basically as follows: number one, the amount of cyanide that would be released from taking even high doses of cyanocobalamin is very small. And so I don't think taking cyanocobalamin is dangerous in any context that I can think of so that's number one. But number two, one of our mechanisms for detoxifying cyanide, and it's not the only mechanism, but it's one of the key mechanisms is to join the cyanide, to cobalamin, to pee it out in the urine.

This Q&A can also be found as part of a much longer episode, here:

078: Ask Me Anything About Nutrition, August 19, 2020

For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at You can sign up for a consultation at 

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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The Masterjohn Q&A Files
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Chris Masterjohn, PhD