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140: Why would ferritin be extremely high when transferrin saturation is low?

Masterjohn Q&A Files Episode 140


Question: Why would ferritin be extremely high when transferrin saturation is low?

Ferritin as a potential indicator of iron overload should not be anywhere near the level that was set to try to rule in biopsy provable hemochromatosis that is just a profoundly negligent approach to setting the range for ferritin. Now, I think part of what has stopped, you know— This mostly is a problem of the binary diagnostic mindset of conventional medicine. So, I'm not saying that this mindset is not useful. It is tremendously useful, but too many people confuse it for a reality when in fact it is a reality distortion filter meant to more efficiently triage people through various treatments or nontreatments.

It may be inflammation as you very well tried to feather out. And if it's not that, it's probably oxidative stress. So, I’m not gonna say that’s the only other thing it could be. And for the record, you cannot rule out hemochromatosis genetics with 23andMe or any other genetic test by anyone because there are a small percentage of hemochromatosis genetics that are not in the HFE genes and no one has a panel for them. And so, it’s improbable that it’s hemochromatosis based on 23andMe. You can’t rule it out, but I would say it’s probably not hemochromatosis because his iron is low. And so, you know, I'm highly suspicious of oxidative stress, which also upregulates ferritin. If you have Testing Nutritional Status: The Ultimate Cheat Sheet, I would measure everything in the oxidative stress section.

This Q&A can also be found as part of a much longer episode, here:

Harnessing the Power of Nutrients
Recording and Transcript of Ask Me Anything About Nutrition | July 27, 2020
Watch now (129 min) | Below you will find the time stamps for specific questions, the relevant links, the private podcast audio version, and the transcript. The time stamps are available to everyone but everything else is reserved for Masterpass members. Learn more about the Masterpass…
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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The Masterjohn Q&A Files
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Chris Masterjohn, PhD