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135: If I use SAMe for depression, what do I need for nutritional balance?

Masterjohn Q&A Files Episode 135


Question: If I use SAMe for depression, what do I need for nutritional balance?

Nutrition wise, I think the most important thing would be to make sure that you have an adequate glycine status. And you know, I don't know what your background is in terms of other issues, but the glycine buffer system, which is how you buffer excess methyl groups, which is what you would have if you take a large bolus of SAMe.

Other nutritional concern would be having enough molybdenum. Generally, you're gonna have enough with 100 mcg a day. If you're eating liver once a week, you probably have enough, but there's no harm in taking like 500 mcg a day, so not really a problem if you want to supplement there just to make sure it's not an issue.

This Q&A can also be found as part of a much longer episode, here:

Harnessing the Power of Nutrients
Recording and Transcript of Ask Me Anything About Nutrition | July 27, 2020
Watch now (129 min) | Below you will find the time stamps for specific questions, the relevant links, the private podcast audio version, and the transcript. The time stamps are available to everyone but everything else is reserved for Masterpass members. Learn more about the Masterpass…
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For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at You can sign up for a consultation at 

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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The Masterjohn Q&A Files
We use Zoom, a video chatting software, in webinar mode. You can ask your question anonymously in text, but you can also ask it publicly, and you can even get "on stage" and share your mic, web cam, or screen with everyone.
Chris Masterjohn, PhD