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132: How to Safely Take Nicotinamide Riboside for Anti-Aging

Chris Masterjohn Lite Episode 132


Nicotinamide riboside (NR) is the best form of niacin to take for anti-aging benefits.

BUT… it could sap your creatine supply, making you weaker, hurting your digestion, or causing you to get depressed.

AND it could mess with your dopamine, giving you “sticky brain” syndrome, causing negative thoughts and emotions to get stuck in your mind.

How do we protect against this? It all comes down to dose, frequency, timing it with meals, and making sure you have enough methyl donors.

Tune in for the details.

Here’s a massive 2-part podcast series I did on niacin with Alex Leaf, which has 52 scientific references:

Niacin Part 1: What It Is and Why You Need It

Niacin Part 2: Blood Tests, Foods, and Supplements

I don’t have an affiliate relationship with Niagen, but I have one with Amazon, and if you would like to purchase the recommended product in a way that offers me a small commission to support the free work I put out at no extra cost to you, you can use this link: 

Here’s a Twitter exchange I had with Charles Brenner, who patented and distributes that product, in which he ignored all my points about creatine: 

Twitter avatar for @ChrisMasterjohn
Chris Masterjohn @ChrisMasterjohn
Twitter avatar for @CharlesMBrenner
Charles Brenner, PhD @CharlesMBrenner
@chance__abbott @ChrisMasterjohn it was a perfectly good question for @ChrisMasterjohn to ask but the human body's methyl system is very well buffered against #nicotinamideriboside



The studies Brenner conducted showing NR causes massive excretion of methyl groups: 

My original video, Why You Should Be Careful With Niacin and Nicotinamide Riboside: 

Start Here for MTHFR and Methylation: 

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Chris Masterjohn Lite
“Chris Masterjohn Lite” is a running series of quick tip videos lasting two to five minutes where the name of the game is “Details? Shmetails! Just tell me what works!”
Chris Masterjohn, PhD